Gene description for Wdr75
Gene name WD repeat domain 75
Gene symbol Wdr75
Other names/aliases 1300003A18Rik
2410118I19Rik
C77608
Species Mus musculus
 Database cross references - Wdr75
ExoCarta ExoCarta_73674
Vesiclepedia VP_73674
Entrez Gene 73674
 Wdr75 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wdr75
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IEA
Biological Process
    rRNA processing GO:0006364 IEA
    ribosomal small subunit biogenesis GO:0042274 ISO
    ribosomal small subunit biogenesis GO:0042274 ISS
    positive regulation of transcription by RNA polymerase I GO:0045943 IBA
    positive regulation of transcription by RNA polymerase I GO:0045943 IEA
    positive regulation of transcription by RNA polymerase I GO:0045943 ISO
    positive regulation of rRNA processing GO:2000234 IBA
    positive regulation of rRNA processing GO:2000234 IEA
    positive regulation of rRNA processing GO:2000234 ISO
Subcellular Localization
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    small-subunit processome GO:0032040 ISO
    small-subunit processome GO:0032040 ISS
 Experiment description of studies that identified Wdr75 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wdr75
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Olfml2a  
Co-fractionation Mus musculus
2 Foxp3  
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Gfra1  
Co-fractionation Mus musculus
View the network image/svg+xml



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