Gene description for C7
Gene name complement component 7
Gene symbol C7
Other names/aliases -
Species Homo sapiens
 Database cross references - C7
ExoCarta ExoCarta_730
Entrez Gene 730
HGNC 1346
MIM 217070
UniProt P10643  
 C7 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for C7
Biological Process
    innate immune response GO:0045087 TAS
    cytolysis GO:0019835 IEA
    cellular sodium ion homeostasis GO:0006883 IEA
    complement activation, alternative pathway GO:0006957 IEA
    complement activation, classical pathway GO:0006958 IEA
    complement activation GO:0006956 TAS
    regulation of complement activation GO:0030449 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    membrane attack complex GO:0005579 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified C7 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for C7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLU 1191
Reconstituted Complex Homo sapiens
2 C5 727
Reconstituted Complex Homo sapiens
3 PLG 5340
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which C7 is involved
PathwayEvidenceSource
Regulation of Complement cascade TAS Reactome
Terminal pathway of complement TAS Reactome





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