Gene description for Setd5
Gene name SET domain containing 5
Gene symbol Setd5
Other names/aliases 2900045N06Rik
C330007C20
C85544
mKIAA1757
Species Mus musculus
 Database cross references - Setd5
ExoCarta ExoCarta_72895
Vesiclepedia VP_72895
Entrez Gene 72895
UniProt Q5XJV7  
 Setd5 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd5
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    methylated histone binding GO:0035064 IBA
    histone H3K9 methyltransferase activity GO:0046974 IDA
    histone H3K36 methyltransferase activity GO:0046975 IMP
    histone H3 methyltransferase activity GO:0140938 IDA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of DNA-templated transcription GO:0006355 IBA
    negative regulation of transcription by RNA polymerase III GO:0016480 IMP
    methylation GO:0032259 IEA
    regulation of DNA-templated transcription elongation GO:0032784 IMP
    cognition GO:0050890 IMP
    regulation of synapse assembly GO:0051963 IMP
    regulation of chromatin organization GO:1902275 IMP
Subcellular Localization
    chromatin GO:0000785 IDA
    euchromatin GO:0000791 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    Set3 complex GO:0034967 IBA
    Rpd3L-Expanded complex GO:0070210 IBA
 Experiment description of studies that identified Setd5 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TTLL5  
Affinity Capture-MS Homo sapiens
2 NCOR1  
Affinity Capture-MS Homo sapiens
3 PARP16 54956
Affinity Capture-MS Homo sapiens
4 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
5 NCOR2  
Affinity Capture-MS Homo sapiens
6 ANKRD11 29123
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Setd5 is involved
No pathways found





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