Gene description for Tmx1
Gene name thioredoxin-related transmembrane protein 1
Gene symbol Tmx1
Other names/aliases 2810425A04Rik
AI465319
Txndc1
Species Mus musculus
 Database cross references - Tmx1
ExoCarta ExoCarta_72736
Vesiclepedia VP_72736
Entrez Gene 72736
UniProt Q8VBT0  
 Tmx1 identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Tmx1
Molecular Function
    protein disulfide isomerase activity GO:0003756 IDA
    protein disulfide isomerase activity GO:0003756 ISO
    enzyme inhibitor activity GO:0004857 ISO
    enzyme inhibitor activity GO:0004857 ISS
    protein-disulfide reductase activity GO:0015035 ISO
    protein-disulfide reductase activity GO:0015035 ISS
    disulfide oxidoreductase activity GO:0015036 IBA
    disulfide oxidoreductase activity GO:0015036 ISO
Biological Process
    negative regulation of triglyceride biosynthetic process GO:0010868 ISO
    negative regulation of triglyceride biosynthetic process GO:0010868 ISS
    response to endoplasmic reticulum stress GO:0034976 IEA
    response to endoplasmic reticulum stress GO:0034976 ISO
    regulation of calcium ion transport GO:0051924 IEA
    regulation of calcium ion transport GO:0051924 ISO
    negative regulation of platelet aggregation GO:0090331 IMP
    negative regulation of platelet aggregation GO:0090331 ISO
    positive regulation of ERAD pathway GO:1904294 ISO
    positive regulation of ERAD pathway GO:1904294 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISS
    endomembrane system GO:0012505 IBA
    mitochondrial membrane GO:0031966 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISO
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISS
 Experiment description of studies that identified Tmx1 in sEVs
1
Experiment ID 264
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tmx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg5  
Affinity Capture-RNA Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Tmx1 is involved
No pathways found





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