Gene description for Tradd
Gene name TNFRSF1A-associated via death domain
Gene symbol Tradd
Other names/aliases 9130005N23Rik
AA930854
Species Mus musculus
 Database cross references - Tradd
ExoCarta ExoCarta_71609
Vesiclepedia VP_71609
Entrez Gene 71609
UniProt Q3U0V2  
 Tradd identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tradd
Molecular Function
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IBA
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IEA
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISO
    tumor necrosis factor receptor binding GO:0005164 IEA
    tumor necrosis factor receptor binding GO:0005164 ISO
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 ISO
    signaling adaptor activity GO:0035591 IDA
    signaling adaptor activity GO:0035591 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    molecular adaptor activity GO:0060090 ISO
    death domain binding GO:0070513 IEA
    death domain binding GO:0070513 ISO
Biological Process
    apoptotic process GO:0006915 RCA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    canonical NF-kappaB signal transduction GO:0007249 IEA
    canonical NF-kappaB signal transduction GO:0007249 ISO
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 TAS
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of interferon-beta production GO:0032728 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 TAS
    TRAIL-activated apoptotic signaling pathway GO:0036462 IEA
    regulation of apoptotic process GO:0042981 RCA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of inflammatory response GO:0050729 IEA
    positive regulation of inflammatory response GO:0050729 ISO
    positive regulation of hair follicle development GO:0051798 IMP
    cellular response to tumor necrosis factor GO:0071356 ISO
    extrinsic apoptotic signaling pathway GO:0097191 IBA
    extrinsic apoptotic signaling pathway GO:0097191 IGI
    extrinsic apoptotic signaling pathway GO:0097191 ISO
    positive regulation of execution phase of apoptosis GO:1900119 ISO
Subcellular Localization
    tumor necrosis factor receptor superfamily complex GO:0002947 IBA
    tumor necrosis factor receptor superfamily complex GO:0002947 IEA
    tumor necrosis factor receptor superfamily complex GO:0002947 ISO
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    protein-containing complex GO:0032991 ISO
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified Tradd in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tradd
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg12  
Positive Genetic Mus musculus
2 Tnf  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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