Gene description for Atp6ap2
Gene name ATPase, H+ transporting, lysosomal accessory protein 2
Gene symbol Atp6ap2
Other names/aliases (P)RR
5730403E06Rik
APT6M8-9
ATP6M8-9
Atp6ip2
M8-9
Species Mus musculus
 Database cross references - Atp6ap2
ExoCarta ExoCarta_70495
Vesiclepedia VP_70495
Entrez Gene 70495
UniProt Q9CYN9  
 Atp6ap2 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Atp6ap2
Molecular Function
    signaling receptor activity GO:0038023 IEA
Biological Process
    angiotensin maturation GO:0002003 IEA
    angiotensin maturation GO:0002003 ISO
    lysosomal lumen acidification GO:0007042 ISO
    lysosomal lumen acidification GO:0007042 ISS
    central nervous system maturation GO:0021626 IMP
    central nervous system maturation GO:0021626 ISO
    rostrocaudal neural tube patterning GO:0021903 IEA
    rostrocaudal neural tube patterning GO:0021903 ISO
    positive regulation of Wnt signaling pathway GO:0030177 IBA
    positive regulation of Wnt signaling pathway GO:0030177 IMP
    positive regulation of Wnt signaling pathway GO:0030177 ISO
    positive regulation of transforming growth factor beta1 production GO:0032914 IEA
    positive regulation of transforming growth factor beta1 production GO:0032914 ISO
    regulation of MAPK cascade GO:0043408 IEA
    regulation of MAPK cascade GO:0043408 ISO
    eye pigmentation GO:0048069 IEA
    eye pigmentation GO:0048069 ISO
    head morphogenesis GO:0060323 IEA
    head morphogenesis GO:0060323 ISO
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISO
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISS
    synaptic vesicle lumen acidification GO:0097401 EXP
    synaptic vesicle lumen acidification GO:0097401 IDA
    synaptic vesicle lumen acidification GO:0097401 IMP
Subcellular Localization
    vacuolar proton-transporting V-type ATPase, V0 domain GO:0000220 ISS
    autophagosome membrane GO:0000421 IEA
    extracellular space GO:0005615 ISO
    lysosome GO:0005764 ISO
    lysosomal membrane GO:0005765 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IEA
    external side of plasma membrane GO:0009897 ISO
    endosome membrane GO:0010008 IDA
    membrane GO:0016020 ISO
    apical plasma membrane GO:0016324 ISO
    vacuolar proton-transporting V-type ATPase complex GO:0016471 ISO
    axon GO:0030424 IEA
    clathrin-coated vesicle membrane GO:0030665 IEA
    synaptic vesicle membrane GO:0030672 IEA
    synaptic vesicle membrane GO:0030672 ISO
    dendritic spine membrane GO:0032591 IEA
    cell body GO:0044297 ISO
    postsynaptic membrane GO:0045211 IEA
 Experiment description of studies that identified Atp6ap2 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp6ap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GLP1R  
PCA Homo sapiens
2 Tmem173  
Proximity Label-MS Mus musculus
3 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml



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