Gene description for Nars
Gene name asparaginyl-tRNA synthetase
Gene symbol Nars
Other names/aliases 3010001M15Rik
AA960128
ASNRS
C78150
Species Mus musculus
 Database cross references - Nars
ExoCarta ExoCarta_70223
Entrez Gene 70223
UniProt Q8BP47  
 Nars identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Nars
Molecular Function
    nucleic acid binding GO:0003676 IEA
    nucleotide binding GO:0000166 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    asparagine-tRNA ligase activity GO:0004816 IEA
    ligase activity GO:0016874 IEA
    ATP binding GO:0005524 IEA
Biological Process
    translation GO:0006412 IEA
    tRNA aminoacylation for protein translation GO:0006418 IEA
    asparaginyl-tRNA aminoacylation GO:0006421 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Nars in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nars is involved
No pathways found





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