Gene description for Foxk2
Gene name forkhead box K2
Gene symbol Foxk2
Other names/aliases 1110054H05Rik
5730434B08Rik
6230415M23Rik
ILF
Ilf1
Species Mus musculus
 Database cross references - Foxk2
ExoCarta ExoCarta_68837
Vesiclepedia VP_68837
Entrez Gene 68837
UniProt Q3UCQ1  
 Foxk2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Foxk2
Molecular Function
    magnesium ion binding GO:0000287 ISO
    magnesium ion binding GO:0000287 ISS
    transcription cis-regulatory region binding GO:0000976 ISO
    transcription cis-regulatory region binding GO:0000976 ISS
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific DNA binding GO:0043565 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    intracellular glucose homeostasis GO:0001678 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    negative regulation of autophagy GO:0010507 IDA
    regulation of glucose metabolic process GO:0010906 IDA
    response to starvation GO:0042594 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    canonical glycolysis GO:0061621 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Foxk2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Foxk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Foxk2 is involved
PathwayEvidenceSource
Deubiquitination IEA Reactome
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
UCH proteinases IEA Reactome





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