Gene description for Gba
Gene name glucosidase, beta, acid
Gene symbol Gba
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gba
ExoCarta ExoCarta_684536
Vesiclepedia VP_684536
Entrez Gene 684536
 Gba identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gba
Molecular Function
    glucosylceramidase activity GO:0004348 IBA
    glucosylceramidase activity GO:0004348 IDA
    glucosylceramidase activity GO:0004348 ISO
    signaling receptor binding GO:0005102 ISO
    scavenger receptor binding GO:0005124 ISO
    beta-glucosidase activity GO:0008422 ISO
    hydrolase activity GO:0016787 ISO
    glucosyltransferase activity GO:0046527 ISO
    steryl-beta-glucosidase activity GO:0050295 ISO
Biological Process
    mitophagy GO:0000423 ISO
    glucosylceramide metabolic process GO:0006678 ISO
    glucosylceramide catabolic process GO:0006680 IBA
    glucosylceramide catabolic process GO:0006680 ISO
    autophagy GO:0006914 ISO
    autophagy GO:0006914 ISO
    mitochondrion organization GO:0007005 ISO
    mitochondrion organization GO:0007005 ISO
    lysosome organization GO:0007040 ISO
    central nervous system development GO:0007417 ISO
    cholesterol metabolic process GO:0008203 IEA
    cholesterol metabolic process GO:0008203 ISO
    determination of adult lifespan GO:0008340 ISO
    cellular response to starvation GO:0009267 ISO
    response to pH GO:0009268 IDA
    microglia differentiation GO:0014004 ISO
    antigen processing and presentation GO:0019882 ISO
    lipid storage GO:0019915 ISO
    cerebellar Purkinje cell layer formation GO:0021694 ISO
    pyramidal neuron differentiation GO:0021859 ISO
    respiratory electron transport chain GO:0022904 ISO
    termination of signal transduction GO:0023021 ISO
    lipid glycosylation GO:0030259 ISO
    neuron projection development GO:0031175 ISO
    negative regulation of protein-containing complex assembly GO:0031333 ISO
    negative regulation of protein-containing complex assembly GO:0031333 ISO
    regulation of TOR signaling GO:0032006 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO
    negative regulation of interleukin-6 production GO:0032715 ISO
    T cell differentiation in thymus GO:0033077 ISO
    response to testosterone GO:0033574 IDA
    regulation of membrane potential GO:0042391 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of protein-containing complex disassembly GO:0043243 ISO
    negative regulation of MAPK cascade GO:0043409 IEA
    negative regulation of MAPK cascade GO:0043409 ISO
    negative regulation of neuron apoptotic process GO:0043524 ISO
    response to estrogen GO:0043627 IDA
    sphingosine biosynthetic process GO:0046512 ISO
    ceramide biosynthetic process GO:0046513 ISO
    cell maturation GO:0048469 ISO
    brain morphogenesis GO:0048854 ISO
    homeostasis of number of cells GO:0048872 ISO
    nervous system process GO:0050877 ISO
    neuromuscular process GO:0050905 ISO
    regulation of protein metabolic process GO:0051246 ISO
    negative regulation of protein metabolic process GO:0051248 ISO
    neuron apoptotic process GO:0051402 ISO
    establishment of skin barrier GO:0061436 IMP
    microglial cell proliferation GO:0061518 ISO
    motor behavior GO:0061744 ISO
    cellular response to tumor necrosis factor GO:0071356 ISO
    hematopoietic stem cell proliferation GO:0071425 ISO
    response to dexamethasone GO:0071548 IDA
    lymphocyte migration GO:0072676 ISO
    response to thyroid hormone GO:0097066 IDA
    skin epidermis development GO:0098773 IMP
    beta-glucoside catabolic process GO:1901805 IDA
    positive regulation of proteolysis involved in protein catabolic process GO:1903052 ISO
    positive regulation of protein lipidation GO:1903061 ISO
    positive regulation of neuronal action potential GO:1904457 ISO
    autophagosome organization GO:1905037 ISO
    positive regulation of type 2 mitophagy GO:1905091 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    lysosome GO:0005764 ISO
    lysosomal membrane GO:0005765 ISO
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 ISO
    trans-Golgi network GO:0005802 ISO
    lysosomal lumen GO:0043202 ISO
 Experiment description of studies that identified Gba in sEVs
1
Experiment ID 96
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gba
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gba is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here