Gene description for Nmb
Gene name neuromedin B
Gene symbol Nmb
Other names/aliases 3110023K12Rik
Species Mus musculus
 Database cross references - Nmb
ExoCarta ExoCarta_68039
Vesiclepedia VP_68039
Entrez Gene 68039
UniProt Q9CR53  
 Nmb identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nmb
Molecular Function
    neuropeptide hormone activity GO:0005184 IBA
    neuromedin B receptor binding GO:0031710 IBA
    neuromedin B receptor binding GO:0031710 ISO
Biological Process
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    neuropeptide signaling pathway GO:0007218 IEA
    positive regulation of cell population proliferation GO:0008284 ISO
    negative regulation of interleukin-6 production GO:0032715 IMP
    positive regulation of interferon-alpha production GO:0032727 IDA
    positive regulation of hormone secretion GO:0046887 IBA
    positive regulation of hormone secretion GO:0046887 ISO
    negative regulation of hormone secretion GO:0046888 ISO
    arachidonate secretion GO:0050482 ISO
    positive regulation of osteoclast proliferation GO:0090290 IMP
    antiviral innate immune response GO:0140374 IDA
    sneeze reflex GO:0160023 IMP
    Leydig cell proliferation GO:0160024 ISS
    sensory perception of itch GO:0160025 IDA
    positive regulation of respiratory gaseous exchange GO:1903942 IDA
    positive regulation of testosterone secretion GO:2000845 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    neuron projection GO:0043005 IBA
    neuron projection GO:0043005 IDA
 Experiment description of studies that identified Nmb in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nmb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here