Gene description for Gipc1
Gene name GIPC PDZ domain containing family, member 1
Gene symbol Gipc1
Other names/aliases GIPC
Glut1CIP
Rgs19ip1
Semcap1
TIP-2
TaxIP2
Species Mus musculus
 Database cross references - Gipc1
ExoCarta ExoCarta_67903
Vesiclepedia VP_67903
Entrez Gene 67903
UniProt Q9Z0G0  
 Gipc1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Gipc1
Molecular Function
    actin binding GO:0003779 IPI
    GTPase activator activity GO:0005096 TAS
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    myosin binding GO:0017022 IPI
    PDZ domain binding GO:0030165 ISO
    identical protein binding GO:0042802 IPI
Biological Process
    protein targeting GO:0006605 IMP
    protein targeting GO:0006605 IPI
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    chemical synaptic transmission GO:0007268 IMP
    glutamate secretion GO:0014047 IMP
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IDA
    regulation of protein stability GO:0031647 IDA
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IDA
    positive regulation of cytokinesis GO:0032467 IEA
    positive regulation of cytokinesis GO:0032467 ISO
    endothelial cell migration GO:0043542 IMP
    positive regulation of melanin biosynthetic process GO:0048023 ISO
    positive regulation of melanin biosynthetic process GO:0048023 ISS
    regulation of synaptic plasticity GO:0048167 IMP
    cellular response to interleukin-7 GO:0098761 IDA
    presynaptic modulation of chemical synaptic transmission GO:0099171 IDA
    presynaptic modulation of chemical synaptic transmission GO:0099171 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    brush border GO:0005903 ISO
    cell cortex GO:0005938 IEA
    cell cortex GO:0005938 ISO
    synaptic vesicle GO:0008021 IDA
    vesicle membrane GO:0012506 IDA
    membrane GO:0016020 IDA
    endocytic vesicle GO:0030139 ISO
    cytoplasmic vesicle GO:0031410 ISO
    dendritic spine GO:0043197 IDA
    dendritic shaft GO:0043198 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Gipc1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gipc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ubc  
Reconstituted Complex Mus musculus
2 Myo6  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Celf1  
Co-fractionation Mus musculus
4 Plekhg5  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 Ntrk2  
Co-fractionation Mus musculus
6 Homer1  
Affinity Capture-MS Mus musculus
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