Gene description for Slc38a2
Gene name solute carrier family 38, member 2
Gene symbol Slc38a2
Other names/aliases 5033402L14Rik
AI316867
ATA2
SAT2
mKIAA1382
Species Mus musculus
 Database cross references - Slc38a2
ExoCarta ExoCarta_67760
Entrez Gene 67760
UniProt Q8CFE6  
 Slc38a2 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Slc38a2
Molecular Function
    symporter activity GO:0015293 IEA
    amino acid transmembrane transporter activity GO:0015171 IDA
Biological Process
    sodium ion transport GO:0006814 IEA
    glycine betaine transport GO:0031460 ISO
    transport GO:0006810 IEA
    amino acid transmembrane transport GO:0003333 IDA
    ion transport GO:0006811 IEA
    amino acid transport GO:0006865 IDA
    alanine transport GO:0032328 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    brush border GO:0005903 ISO
    neuronal cell body GO:0043025 ISO
    plasma membrane GO:0005886 ISO
    sarcolemma GO:0042383 ISO
    axon GO:0030424 ISO
    dendrite GO:0030425 ISO
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified Slc38a2 in exosomes
1
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc38a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc38a2 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane IEA Reactome
Glutamate Neurotransmitter Release Cycle IEA Reactome





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