Gene description for Rnf213
Gene name ring finger protein 213
Gene symbol Rnf213
Other names/aliases 6030403J01
D11Ertd759e
mKIAA1554
Species Mus musculus
 Database cross references - Rnf213
ExoCarta ExoCarta_672511
Vesiclepedia VP_672511
Entrez Gene 672511
 Rnf213 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rnf213
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    ubiquitin-protein transferase activity GO:0004842 IBA
    ubiquitin-protein transferase activity GO:0004842 ISO
    ubiquitin-protein transferase activity GO:0004842 ISS
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 ISO
    ATP hydrolysis activity GO:0016887 ISS
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 ISO
    ubiquitin protein ligase activity GO:0061630 ISS
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    angiogenesis GO:0001525 IMP
    angiogenesis GO:0001525 ISO
    sprouting angiogenesis GO:0002040 IBA
    sprouting angiogenesis GO:0002040 ISO
    sprouting angiogenesis GO:0002040 ISS
    immune system process GO:0002376 IEA
    chromatin remodeling GO:0006338 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    protein ubiquitination GO:0016567 ISO
    protein ubiquitination GO:0016567 ISS
    regulation of lipid metabolic process GO:0019216 ISO
    regulation of lipid metabolic process GO:0019216 ISS
    defense response to bacterium GO:0042742 IMP
    defense response to bacterium GO:0042742 ISO
    protein autoubiquitination GO:0051865 ISO
    protein autoubiquitination GO:0051865 ISS
    protein K63-linked ubiquitination GO:0070534 ISO
    protein K63-linked ubiquitination GO:0070534 ISS
    xenophagy GO:0098792 ISO
    xenophagy GO:0098792 ISS
    lipid ubiquitination GO:0120323 IMP
    lipid ubiquitination GO:0120323 ISO
    lipid droplet formation GO:0140042 ISO
    lipid droplet formation GO:0140042 ISS
    chromatin looping GO:0140588 IEA
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 IBA
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 ISO
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 ISS
Subcellular Localization
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Rnf213 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rnf213
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kcna3  
Affinity Capture-MS Mus musculus
2 Fancd2  
Affinity Capture-MS Mus musculus
3 Ubc  
Reconstituted Complex Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rnf213 is involved
No pathways found





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