Gene description for Nradd
Gene name neurotrophin receptor associated death domain
Gene symbol Nradd
Other names/aliases 2610311B09Rik
BB104149
NRDD
NRH2
PLAIDD
Species Mus musculus
 Database cross references - Nradd
ExoCarta ExoCarta_67169
Vesiclepedia VP_67169
Entrez Gene 67169
UniProt Q8CJ26  
 Nradd identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Nradd
Molecular Function
    death receptor activity GO:0005035 IBA
    neurotrophin p75 receptor binding GO:0005166 ISO
    protein binding GO:0005515 IPI
    coreceptor activity GO:0015026 IBA
    nerve growth factor binding GO:0048406 IBA
Biological Process
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IEA
    Rho protein signal transduction GO:0007266 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear envelope lumen GO:0005641 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IBA
    membrane GO:0016020 IDA
    lamellipodium GO:0030027 IDA
    neuron projection membrane GO:0032589 ISO
    cell body membrane GO:0044298 ISO
 Experiment description of studies that identified Nradd in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nradd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nradd is involved
No pathways found





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