Gene description for Tril
Gene name TLR4 interactor with leucine-rich repeats
Gene symbol Tril
Other names/aliases 1200009O22Rik
AI316813
mKIAA0644
Species Mus musculus
 Database cross references - Tril
ExoCarta ExoCarta_66873
Vesiclepedia VP_66873
Entrez Gene 66873
UniProt Q9DBY4  
 Tril identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tril
Molecular Function
    lipopolysaccharide binding GO:0001530 IBA
    lipopolysaccharide binding GO:0001530 IEA
    lipopolysaccharide binding GO:0001530 ISO
Biological Process
    regulation of cytokine production involved in immune response GO:0002718 IBA
    regulation of cytokine production involved in immune response GO:0002718 IEA
    regulation of cytokine production involved in immune response GO:0002718 ISO
    inflammatory response GO:0006954 IEA
    toll-like receptor 4 signaling pathway GO:0034142 IBA
    toll-like receptor 4 signaling pathway GO:0034142 IEA
    toll-like receptor 4 signaling pathway GO:0034142 ISO
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular matrix GO:0031012 IBA
    lipopolysaccharide receptor complex GO:0046696 IBA
    lipopolysaccharide receptor complex GO:0046696 IEA
    lipopolysaccharide receptor complex GO:0046696 ISO
 Experiment description of studies that identified Tril in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tril
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Tril is involved
No pathways found





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