Gene description for Snx9
Gene name sorting nexin 9
Gene symbol Snx9
Other names/aliases 2700073N08Rik
SDP1
SH3PX1
Species Mus musculus
 Database cross references - Snx9
ExoCarta ExoCarta_66616
Vesiclepedia VP_66616
Entrez Gene 66616
UniProt Q91VH2  
 Snx9 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx9
Molecular Function
    protein binding GO:0005515 IPI
    1-phosphatidylinositol binding GO:0005545 ISO
    1-phosphatidylinositol binding GO:0005545 ISS
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IDA
    phosphatidylinositol binding GO:0035091 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    Arp2/3 complex binding GO:0071933 IEA
    Arp2/3 complex binding GO:0071933 ISO
Biological Process
    mitotic cytokinesis GO:0000281 ISO
    mitotic cytokinesis GO:0000281 ISS
    intracellular protein transport GO:0006886 IMP
    intracellular protein transport GO:0006886 ISO
    endocytosis GO:0006897 IBA
    endocytosis GO:0006897 ISO
    endocytosis GO:0006897 ISS
    receptor-mediated endocytosis GO:0006898 ISO
    receptor-mediated endocytosis GO:0006898 ISS
    endosomal transport GO:0016197 IBA
    endosomal transport GO:0016197 ISO
    endosomal transport GO:0016197 ISS
    positive regulation of actin filament polymerization GO:0030838 IDA
    cleavage furrow formation GO:0036089 IBA
    cleavage furrow formation GO:0036089 ISO
    cleavage furrow formation GO:0036089 ISS
    positive regulation of GTPase activity GO:0043547 ISO
    positive regulation of GTPase activity GO:0043547 ISS
    positive regulation of protein kinase activity GO:0045860 ISO
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IEA
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO
    lipid tube assembly GO:0060988 ISO
    lipid tube assembly GO:0060988 ISS
    protein-containing complex assembly GO:0065003 ISO
    protein-containing complex assembly GO:0065003 ISS
    plasma membrane tubulation GO:0097320 IBA
    plasma membrane tubulation GO:0097320 IEA
    plasma membrane tubulation GO:0097320 ISO
    regulation of synaptic vesicle endocytosis GO:1900242 IEA
    regulation of synaptic vesicle endocytosis GO:1900242 ISO
Subcellular Localization
    ruffle GO:0001726 IEA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    trans-Golgi network GO:0005802 ISO
    trans-Golgi network GO:0005802 ISS
    cytosol GO:0005829 IPI
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    clathrin-coated pit GO:0005905 ISO
    clathrin-coated pit GO:0005905 ISS
    clathrin-coated vesicle GO:0030136 ISO
    clathrin-coated vesicle GO:0030136 ISS
    cytoplasmic vesicle membrane GO:0030659 ISO
    cytoplasmic vesicle membrane GO:0030659 ISS
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 ISO
    cytoplasmic vesicle GO:0031410 ISS
    cuticular plate GO:0032437 IDA
    presynapse GO:0098793 IEA
    presynapse GO:0098793 ISO
 Experiment description of studies that identified Snx9 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Insr  
Affinity Capture-Western Mus musculus
2 Snx8  
Co-fractionation Mus musculus
3 Atg5  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Igf1r 16001
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here