Gene description for SLC11A1
Gene name solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Gene symbol SLC11A1
Other names/aliases LSH
NRAMP
NRAMP1
Species Homo sapiens
 Database cross references - SLC11A1
ExoCarta ExoCarta_6556
Vesiclepedia VP_6556
Entrez Gene 6556
HGNC 10907
MIM 600266
UniProt P49279  
 SLC11A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC11A1
Molecular Function
    iron ion transmembrane transporter activity GO:0005381 IBA
    iron ion transmembrane transporter activity GO:0005381 IDA
    manganese ion transmembrane transporter activity GO:0005384 IBA
    manganese ion transmembrane transporter activity GO:0005384 IDA
    manganese ion transmembrane transporter activity GO:0005384 ISS
    cadmium ion transmembrane transporter activity GO:0015086 IBA
    protein homodimerization activity GO:0042803 IDA
    transition metal ion transmembrane transporter activity GO:0046915 IGI
    metal cation:proton antiporter activity GO:0051139 IBA
    metal cation:proton antiporter activity GO:0051139 IDA
    metal cation:proton antiporter activity GO:0051139 IGI
    metal cation:proton antiporter activity GO:0051139 TAS
Biological Process
    negative regulation of cytokine production GO:0001818 ISS
    positive regulation of cytokine production GO:0001819 ISS
    T cell proliferation involved in immune response GO:0002309 ISS
    positive regulation of dendritic cell antigen processing and presentation GO:0002606 ISS
    positive regulation of T-helper 1 type immune response GO:0002827 ISS
    iron ion transport GO:0006826 IDA
    iron ion transport GO:0006826 IMP
    manganese ion transport GO:0006828 IBA
    manganese ion transport GO:0006828 IDA
    manganese ion transport GO:0006828 ISS
    intracellular iron ion homeostasis GO:0006879 IMP
    phagocytosis GO:0006909 ISS
    inflammatory response GO:0006954 ISS
    vacuolar acidification GO:0007035 ISS
    response to bacterium GO:0009617 IDA
    positive regulation of gene expression GO:0010628 ISS
    nitrite transport GO:0015707 ISS
    antimicrobial humoral response GO:0019730 TAS
    metal ion transport GO:0030001 ISS
    response to lipopolysaccharide GO:0032496 ISS
    positive regulation of type II interferon production GO:0032729 ISS
    positive regulation of type II interferon production GO:0032729 ISS
    response to type II interferon GO:0034341 ISS
    iron ion transmembrane transport GO:0034755 IBA
    wound healing GO:0042060 ISS
    macrophage activation GO:0042116 ISS
    defense response to bacterium GO:0042742 ISS
    defense response to protozoan GO:0042832 ISS
    MHC class II biosynthetic process GO:0045342 ISS
    cell redox homeostasis GO:0045454 TAS
    respiratory burst GO:0045730 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    antigen processing and presentation of peptide antigen GO:0048002 ISS
    mRNA stabilization GO:0048255 ISS
    positive regulation of phagocytosis GO:0050766 ISS
    defense response to Gram-negative bacterium GO:0050829 ISS
    establishment of localization in cell GO:0051649 IEA
    multicellular organismal-level iron ion homeostasis GO:0060586 ISS
    cadmium ion transmembrane transport GO:0070574 IGI
    manganese ion transmembrane transport GO:0071421 IEA
    cellular detoxification of cadmium ion GO:0098849 IGI
    proton transmembrane transport GO:1902600 IEA
    L-arginine transmembrane transport GO:1903826 IEA
Subcellular Localization
    lysosome GO:0005764 ISS
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 ISS
    late endosome GO:0005770 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IMP
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 IBA
    phagocytic vesicle membrane GO:0030670 IBA
    phagocytic vesicle membrane GO:0030670 IDA
    late endosome membrane GO:0031902 ISS
    late endosome membrane GO:0031902 TAS
    tertiary granule membrane GO:0070821 IDA
    tertiary granule membrane GO:0070821 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified SLC11A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC11A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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