Gene description for Aldh3a2
Gene name aldehyde dehydrogenase 3 family, member A2
Gene symbol Aldh3a2
Other names/aliases Aldh4
FALDH
Species Rattus norvegicus
 Database cross references - Aldh3a2
ExoCarta ExoCarta_65183
Vesiclepedia VP_65183
Entrez Gene 65183
UniProt P30839  
 Aldh3a2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Aldh3a2
Molecular Function
    3-chloroallyl aldehyde dehydrogenase activity GO:0004028 IBA
    3-chloroallyl aldehyde dehydrogenase activity GO:0004028 IDA
    aldehyde dehydrogenase (NAD+) activity GO:0004029 IBA
    aldehyde dehydrogenase (NAD+) activity GO:0004029 ISO
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IEA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    long-chain-alcohol oxidase activity GO:0046577 IEA
    long-chain-alcohol oxidase activity GO:0046577 ISO
    long-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0050061 IEA
    long-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0050061 ISO
    long-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0050061 ISS
    medium-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0052814 IEA
    medium-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0052814 ISO
    medium-chain fatty aldehyde dehydrogenase (NAD+) activity GO:0052814 ISS
Biological Process
    response to reactive oxygen species GO:0000302 IDA
    aldehyde metabolic process GO:0006081 IBA
    aldehyde metabolic process GO:0006081 IEA
    aldehyde metabolic process GO:0006081 ISO
    fatty acid metabolic process GO:0006631 IEA
    sesquiterpenoid metabolic process GO:0006714 ISO
    central nervous system development GO:0007417 IEA
    central nervous system development GO:0007417 ISO
    peripheral nervous system development GO:0007422 IEA
    peripheral nervous system development GO:0007422 ISO
    epidermis development GO:0008544 IEA
    epidermis development GO:0008544 ISO
    phytol metabolic process GO:0033306 IEA
    phytol metabolic process GO:0033306 ISO
    formaldehyde metabolic process GO:0046292 IDA
    hexadecanal metabolic process GO:0046458 IEA
    hexadecanal metabolic process GO:0046458 ISO
    hexadecanal metabolic process GO:0046458 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    peroxisome GO:0005777 ISO
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Aldh3a2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh3a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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