Gene description for Tmed2
Gene name	transmembrane emp24 domain trafficking protein 2
Gene symbol	Tmed2
Other names/aliases	Rnp24
Species	Rattus norvegicus
Database cross references - Tmed2
ExoCarta	ExoCarta_65165
Vesiclepedia	VP_65165
Entrez Gene	65165
UniProt	Q63524
Tmed2 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Tmed2

Molecular Function     frizzled binding GO:0005109 IEA     frizzled binding GO:0005109 ISO     smoothened binding GO:0005119 IEA     smoothened binding GO:0005119 ISO     protein binding GO:0005515 IPI Biological Process     in utero embryonic development GO:0001701 ISO     somitogenesis GO:0001756 ISO     neural tube closure GO:0001843 IEA     neural tube closure GO:0001843 ISO     embryonic placenta development GO:0001892 ISO     maternal placenta development GO:0001893 IEA     maternal placenta development GO:0001893 ISO     heart looping GO:0001947 IEA     heart looping GO:0001947 ISO     intracellular protein transport GO:0006886 IBA     intracellular protein transport GO:0006886 IEA     intracellular protein transport GO:0006886 ISO     intracellular protein transport GO:0006886 NAS     endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA     vesicle targeting GO:0006903 NAS     inflammatory response GO:0006954 IEA     inflammatory response GO:0006954 ISO     endoplasmic reticulum organization GO:0007029 ISO     Golgi organization GO:0007030 IBA     Golgi organization GO:0007030 IEA     Golgi organization GO:0007030 ISO     Golgi organization GO:0007030 ISS     protein localization GO:0008104 ISO     protein secretion GO:0009306 IEA     protein secretion GO:0009306 ISO     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     somite rostral/caudal axis specification GO:0032525 IEA     somite rostral/caudal axis specification GO:0032525 ISO     negative regulation of GTPase activity GO:0034260 ISO     negative regulation of GTPase activity GO:0034260 ISS     multicellular organism growth GO:0035264 IEA     multicellular organism growth GO:0035264 ISO     post-anal tail morphogenesis GO:0036342 IEA     post-anal tail morphogenesis GO:0036342 ISO     PERK-mediated unfolded protein response GO:0036499 IEA     PERK-mediated unfolded protein response GO:0036499 ISO     negative regulation of smoothened signaling pathway GO:0045879 IEA     negative regulation of smoothened signaling pathway GO:0045879 ISO     embryonic morphogenesis GO:0048598 ISO     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     branching involved in labyrinthine layer morphogenesis GO:0060670 ISO     labyrinthine layer blood vessel development GO:0060716 IEA     labyrinthine layer blood vessel development GO:0060716 ISO     chorion development GO:0060717 IEA     chorion development GO:0060717 ISO     maintenance of protein localization in organelle GO:0072595 IEA     maintenance of protein localization in organelle GO:0072595 ISO     protein localization to plasma membrane GO:0072659 IEA     protein localization to plasma membrane GO:0072659 ISO     protein localization to plasma membrane GO:0072659 ISS     endoplasmic reticulum membrane organization GO:0090158 IEA     endoplasmic reticulum membrane organization GO:0090158 ISO     negative regulation of protein localization to plasma membrane GO:1903077 IEA     negative regulation of protein localization to plasma membrane GO:1903077 ISO     negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation GO:1903912 ISO     allantois development GO:1905069 IEA     allantois development GO:1905069 ISO     regulation of SREBP signaling pathway GO:2000638 IEA     regulation of SREBP signaling pathway GO:2000638 ISO Subcellular Localization     endoplasmic reticulum GO:0005783 IBA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     endoplasmic reticulum membrane GO:0005789 IEA     endoplasmic reticulum membrane GO:0005789 ISO     endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IBA     endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO     endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISS     Golgi apparatus GO:0005794 IBA     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISS     membrane GO:0016020 IDA     COPII-coated ER to Golgi transport vesicle GO:0030134 IBA     COPI-coated vesicle GO:0030137 IDA     COPI-coated vesicle GO:0030137 ISS     cytoplasmic vesicle membrane GO:0030659 IEA     COPI-coated vesicle membrane GO:0030663 IEA     Golgi cisterna membrane GO:0032580 IEA     endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA     zymogen granule membrane GO:0042589 IDA     intracellular membrane-bounded organelle GO:0043231 ISO