Gene description for Tfrc
Gene name transferrin receptor
Gene symbol Tfrc
Other names/aliases Trfr
Species Rattus norvegicus
 Database cross references - Tfrc
ExoCarta ExoCarta_64678
Entrez Gene 64678
 Tfrc identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Tfrc
Molecular Function
    double-stranded RNA binding GO:0003725 ISO
    identical protein binding GO:0042802 ISO
    transferrin receptor activity GO:0004998 TAS
    chaperone binding GO:0051087 IPI
    glycoprotein binding GO:0001948 ISO
    poly(A) RNA binding GO:0044822 ISO
    transferrin transmembrane transporter activity GO:0033570 IDA
    Hsp70 protein binding GO:0030544 IPI
Biological Process
    cellular response to drug GO:0035690 ISO
    positive regulation of bone resorption GO:0045780 ISO
    response to iron ion GO:0010039 IEP
    cellular iron ion homeostasis GO:0006879 ISO
    osteoclast differentiation GO:0030316 ISO
    response to nutrient GO:0007584 IEP
    response to organic substance GO:0010033 IEP
    acute-phase response GO:0006953 IEP
    response to manganese ion GO:0010042 IEP
    iron ion import GO:0097286 ISO
    regulation of cell proliferation GO:0042127 ISO
    regulation of cell growth GO:0001558 ISO
    response to inorganic substance GO:0010035 IEP
    response to hypoxia GO:0001666 IEP
    transferrin transport GO:0033572 IDA
    aging GO:0007568 IEP
    receptor-mediated endocytosis GO:0006898 IEA
    response to retinoic acid GO:0032526 IEP
    response to copper ion GO:0046688 IEP
Subcellular Localization
    extracellular vesicle GO:1903561 ISO
    recycling endosome membrane GO:0055038 IDA
    blood microparticle GO:0072562 ISO
    endosome GO:0005768 ISO
    recycling endosome GO:0055037 ISO
    membrane GO:0016020 ISO
    coated pit GO:0005905 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    HFE-transferrin receptor complex GO:1990712 ISO
    extracellular exosome GO:0070062 ISO
    external side of plasma membrane GO:0009897 ISO
    cytoplasmic membrane-bounded vesicle GO:0016023 ISO
    integral component of membrane GO:0016021 IEA
    mitochondrion GO:0005739 IDA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cell surface GO:0009986 ISO
    melanosome GO:0042470 IEA
    plasma membrane GO:0005886 ISO
    cell GO:0005623 ISO
 Experiment description of studies that identified Tfrc in exosomes
1
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Mass spectrometry [MALDI TOF]
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
2
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
 Protein-protein interactions for Tfrc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tfrc is involved
No pathways found





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