Gene description for Aldh1l1
Gene name aldehyde dehydrogenase 1 family, member L1
Gene symbol Aldh1l1
Other names/aliases FDH
Fthfd
Species Rattus norvegicus
 Database cross references - Aldh1l1
ExoCarta ExoCarta_64392
Vesiclepedia VP_64392
Entrez Gene 64392
UniProt P28037  
 Aldh1l1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Aldh1l1
Molecular Function
    aldehyde dehydrogenase (NAD+) activity GO:0004029 IBA
    aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 IDA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IBA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IDA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IEA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IMP
    formyltetrahydrofolate dehydrogenase activity GO:0016155 ISO
    formyltetrahydrofolate dehydrogenase activity GO:0016155 TAS
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IEA
    aldehyde dehydrogenase (NADP+) activity GO:0033721 IDA
    protein-containing complex binding GO:0044877 IDA
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    NADPH regeneration GO:0006740 IDA
    NADPH regeneration GO:0006740 IEA
    NADPH regeneration GO:0006740 ISO
    biosynthetic process GO:0009058 IEA
    10-formyltetrahydrofolate catabolic process GO:0009258 IDA
    10-formyltetrahydrofolate catabolic process GO:0009258 IEA
    10-formyltetrahydrofolate catabolic process GO:0009258 IMP
    10-formyltetrahydrofolate catabolic process GO:0009258 ISO
    tetrahydrofolate biosynthetic process GO:0046654 TAS
    folic acid metabolic process GO:0046655 IDA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified Aldh1l1 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh1l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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