Gene description for MMP25
Gene name matrix metallopeptidase 25
Gene symbol MMP25
Other names/aliases MMP-25
MMP20
MMP20A
MMPL1
MT-MMP 6
MT-MMP6
MT6-MMP
MT6MMP
MTMMP6
Species Homo sapiens
 Database cross references - MMP25
ExoCarta ExoCarta_64386
Vesiclepedia VP_64386
Entrez Gene 64386
HGNC 14246
MIM 608482
UniProt Q9NPA2  
 MMP25 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MMP25
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 NAS
    inflammatory response GO:0006954 NAS
    extracellular matrix organization GO:0030198 IBA
    collagen catabolic process GO:0030574 IBA
    hard palate development GO:0060022 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    extracellular matrix GO:0031012 NAS
    specific granule membrane GO:0035579 TAS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified MMP25 in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMP25
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLU 1191
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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