Gene description for Mthfd1
Gene name	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Gene symbol	Mthfd1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Mthfd1
ExoCarta	ExoCarta_64300
Vesiclepedia	VP_64300
Entrez Gene	64300
UniProt	P27653
Mthfd1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046

Gene ontology annotations for Mthfd1

Molecular Function     formate-tetrahydrofolate ligase activity GO:0004329 IEA     formate-tetrahydrofolate ligase activity GO:0004329 ISO     formate-tetrahydrofolate ligase activity GO:0004329 ISS     formate-tetrahydrofolate ligase activity GO:0004329 TAS     methenyltetrahydrofolate cyclohydrolase activity GO:0004477 IBA     methenyltetrahydrofolate cyclohydrolase activity GO:0004477 IEA     methenyltetrahydrofolate cyclohydrolase activity GO:0004477 ISO     methenyltetrahydrofolate cyclohydrolase activity GO:0004477 ISS     methenyltetrahydrofolate cyclohydrolase activity GO:0004477 TAS     methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004486 ISO     methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity GO:0004486 TAS     methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487 IEA     methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0004487 ISO     methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IBA     methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IEA     methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 ISO     methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 ISS     ATP binding GO:0005524 IEA Biological Process     L-histidine biosynthetic process GO:0000105 IEA     neutrophil homeostasis GO:0001780 IEA     neutrophil homeostasis GO:0001780 ISO     neural tube closure GO:0001843 IEA     neural tube closure GO:0001843 ISO     purine nucleotide biosynthetic process GO:0006164 ISO     purine nucleotide biosynthetic process GO:0006164 ISO     purine nucleotide biosynthetic process GO:0006164 ISS     methionine metabolic process GO:0006555 ISO     one-carbon metabolic process GO:0006730 IEP     one-carbon metabolic process GO:0006730 ISO     heart development GO:0007507 IEA     heart development GO:0007507 ISO     serine family amino acid metabolic process GO:0009069 ISO     serine family amino acid biosynthetic process GO:0009070 IEA     serine family amino acid biosynthetic process GO:0009070 ISO     methionine biosynthetic process GO:0009086 IEA     methionine biosynthetic process GO:0009086 ISO     purine ribonucleotide biosynthetic process GO:0009152 IEA     purine ribonucleotide biosynthetic process GO:0009152 ISO     10-formyltetrahydrofolate biosynthetic process GO:0009257 IEA     10-formyltetrahydrofolate biosynthetic process GO:0009257 ISO     transsulfuration GO:0019346 IEA     transsulfuration GO:0019346 ISO     response to nitrogen dioxide GO:0035713 IEP     tetrahydrofolate interconversion GO:0035999 IBA     tetrahydrofolate interconversion GO:0035999 IEA     tetrahydrofolate interconversion GO:0035999 ISO     tetrahydrofolate interconversion GO:0035999 ISS     tetrahydrofolate metabolic process GO:0046653 TAS     somite development GO:0061053 IEA     somite development GO:0061053 ISO Subcellular Localization     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO