Gene description for Ralb
Gene name v-ral simian leukemia viral oncogene homolog B (ras related)
Gene symbol Ralb
Other names/aliases 5730472O18Rik
Species Mus musculus
 Database cross references - Ralb
ExoCarta ExoCarta_64143
Vesiclepedia VP_64143
Entrez Gene 64143
UniProt Q9JIW9  
 Ralb identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ralb
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    G protein activity GO:0003925 IEA
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    GDP binding GO:0019003 IBA
    GDP binding GO:0019003 IEA
    GDP binding GO:0019003 ISO
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
Biological Process
    regulation of exocyst assembly GO:0001928 ISO
    regulation of exocyst assembly GO:0001928 ISS
    positive regulation of protein phosphorylation GO:0001934 ISO
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IEA
    Ras protein signal transduction GO:0007265 IBA
    cellular response to starvation GO:0009267 IEA
    cellular response to starvation GO:0009267 ISO
    receptor internalization GO:0031623 IEA
    receptor internalization GO:0031623 ISO
    negative regulation of protein binding GO:0032091 ISO
    positive regulation of protein binding GO:0032092 ISO
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISO
    cell division GO:0051301 IEA
    regulation of exocyst localization GO:0060178 ISO
    regulation of exocyst localization GO:0060178 ISS
    cellular response to exogenous dsRNA GO:0071360 IEA
    cellular response to exogenous dsRNA GO:0071360 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    positive regulation of autophagosome assembly GO:2000786 IEA
    positive regulation of autophagosome assembly GO:2000786 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    midbody GO:0030496 ISO
    midbody GO:0030496 ISS
 Experiment description of studies that identified Ralb in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ralb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ralb is involved
No pathways found





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