Gene description for Enpep
Gene name glutamyl aminopeptidase
Gene symbol Enpep
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Enpep
ExoCarta ExoCarta_64017
Vesiclepedia VP_64017
Entrez Gene 64017
UniProt P50123  
 Enpep identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Enpep
Molecular Function
    aminopeptidase activity GO:0004177 IDA
    aminopeptidase activity GO:0004177 IEA
    aminopeptidase activity GO:0004177 ISO
    peptidase activity GO:0008233 ISO
    metallopeptidase activity GO:0008237 IEA
    zinc ion binding GO:0008270 IBA
    zinc ion binding GO:0008270 IEA
    peptide binding GO:0042277 IBA
    peptide binding GO:0042277 IDA
    metalloaminopeptidase activity GO:0070006 IBA
    metalloaminopeptidase activity GO:0070006 IEA
    metalloaminopeptidase activity GO:0070006 ISO
    metalloaminopeptidase activity GO:0070006 ISS
Biological Process
    angiogenesis GO:0001525 IEA
    angiogenesis GO:0001525 ISO
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 IEA
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISO
    regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 ISS
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
    regulation of blood pressure GO:0008217 IBA
    cell population proliferation GO:0008283 IEA
    cell population proliferation GO:0008283 ISO
    cell population proliferation GO:0008283 ISS
    cell migration GO:0016477 IEA
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    protein processing GO:0016485 IDA
    glomerulus development GO:0032835 IEA
    glomerulus development GO:0032835 ISO
    peptide catabolic process GO:0043171 IBA
    peptide catabolic process GO:0043171 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    brush border GO:0005903 IEA
    brush border GO:0005903 ISO
    external side of plasma membrane GO:0009897 IEA
    external side of plasma membrane GO:0009897 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    cytoplasmic vesicle GO:0031410 IEA
    cytoplasmic vesicle GO:0031410 ISO
    brush border membrane GO:0031526 IDA
    apical part of cell GO:0045177 ISO
 Experiment description of studies that identified Enpep in sEVs
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Enpep
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Enpep is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome
Metabolism of proteins IEA Reactome
Peptide hormone metabolism IEA Reactome





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