Gene description for Acaca
Gene name acetyl-CoA carboxylase alpha
Gene symbol Acaca
Other names/aliases ACC1
Acac
Species Rattus norvegicus
 Database cross references - Acaca
ExoCarta ExoCarta_60581
Vesiclepedia VP_60581
Entrez Gene 60581
UniProt P11497  
 Acaca identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Acaca
Molecular Function
    acetyl-CoA carboxylase activity GO:0003989 IBA
    acetyl-CoA carboxylase activity GO:0003989 IDA
    acetyl-CoA carboxylase activity GO:0003989 IEA
    acetyl-CoA carboxylase activity GO:0003989 ISO
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 IDA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    tissue homeostasis GO:0001894 IEA
    tissue homeostasis GO:0001894 ISO
    acetyl-CoA metabolic process GO:0006084 IEA
    acetyl-CoA metabolic process GO:0006084 ISO
    lipid metabolic process GO:0006629 ISO
    fatty acid biosynthetic process GO:0006633 IBA
    fatty acid biosynthetic process GO:0006633 IDA
    fatty acid biosynthetic process GO:0006633 IEA
    fatty acid biosynthetic process GO:0006633 ISO
    response to nutrient GO:0007584 IEP
    lipid biosynthetic process GO:0008610 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    response to organic cyclic compound GO:0014070 IMP
    response to nutrient levels GO:0031667 IEP
    protein homotetramerization GO:0051289 IEA
    protein homotetramerization GO:0051289 ISO
    protein homotetramerization GO:0051289 ISS
    lipid homeostasis GO:0055088 IEA
    lipid homeostasis GO:0055088 ISO
    cellular response to prostaglandin E stimulus GO:0071380 IEA
    cellular response to prostaglandin E stimulus GO:0071380 ISO
    malonyl-CoA biosynthetic process GO:2001295 IEA
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
 Experiment description of studies that identified Acaca in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Acaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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