Gene description for Lmna
Gene name lamin A/C
Gene symbol Lmna
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lmna
ExoCarta ExoCarta_60374
Entrez Gene 60374
 Lmna identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Lmna
Molecular Function
    protein phosphatase 1 binding GO:0008157 IPI
Biological Process
    positive regulation of cell aging GO:0090343 ISS
    nuclear envelope organization GO:0006998 ISO
    sterol regulatory element binding protein import into nucleus GO:0035105 ISO
    positive regulation of osteoblast differentiation GO:0045669 IMP
    negative regulation of adipose tissue development GO:1904178 IMP
    regulation of protein localization to nucleus GO:1900180 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 ISO
    protein localization to nucleus GO:0034504 ISS
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of release of cytochrome c from mitochondria GO:0090201 ISO
    spermatogenesis GO:0007283 IEP
    nucleus organization GO:0006997 ISO
    regulation of cell migration GO:0030334 ISO
    muscle organ development GO:0007517 ISO
    ventricular cardiac muscle cell development GO:0055015 ISO
    response to mechanical stimulus GO:0009612 IEP
Subcellular Localization
    nuclear membrane GO:0031965 ISO
    cytoplasm GO:0005737 ISO
    cell GO:0005623 ISO
    nuclear lamina GO:0005652 IEA
    nuclear envelope GO:0005635 ISS
    intermediate filament GO:0005882 IEA
    nucleoplasm GO:0005654 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    lamin filament GO:0005638 ISO
    nuclear matrix GO:0016363 IDA
    nucleus GO:0005634 ISO
    intracellular GO:0005622 ISO
 Experiment description of studies that identified Lmna in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lmna
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lmna is involved
No pathways found





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