Gene description for Tmem27
Gene name transmembrane protein 27
Gene symbol Tmem27
Other names/aliases NX-17
Nx17
collectrin
Species Rattus norvegicus
 Database cross references - Tmem27
ExoCarta ExoCarta_57395
Vesiclepedia VP_57395
Entrez Gene 57395
UniProt Q9ESG3  
 Tmem27 identified in sEVs derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Tmem27
Molecular Function
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
Biological Process
    calcium-ion regulated exocytosis GO:0017156 IEA
    calcium-ion regulated exocytosis GO:0017156 ISO
    regulation of transmembrane transporter activity GO:0022898 ISO
    SNARE complex assembly GO:0035493 IEA
    SNARE complex assembly GO:0035493 ISO
    insulin secretion involved in cellular response to glucose stimulus GO:0035773 IEA
    insulin secretion involved in cellular response to glucose stimulus GO:0035773 ISO
    positive regulation of amino acid transport GO:0051957 IBA
    positive regulation of amino acid transport GO:0051957 ISO
    positive regulation of L-proline import across plasma membrane GO:1905737 IEA
    positive regulation of L-proline import across plasma membrane GO:1905737 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    brush border membrane GO:0031526 IEA
    brush border membrane GO:0031526 ISO
 Experiment description of studies that identified Tmem27 in sEVs
1
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tmem27
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmem27 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here