Gene description for Tmem27
Gene name transmembrane protein 27
Gene symbol Tmem27
Other names/aliases NX-17
Nx17
collectrin
Species Rattus norvegicus
 Database cross references - Tmem27
ExoCarta ExoCarta_57395
Entrez Gene 57395
UniProt Q9ESG3  
 Tmem27 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Tmem27
Molecular Function
    metallopeptidase activity GO:0008237 IEA
    peptidyl-dipeptidase activity GO:0008241 IEA
Biological Process
    positive regulation of calcium ion-dependent exocytosis GO:0045956 ISO
    positive regulation of amino acid transport GO:0051957 ISO
    proteolysis GO:0006508 IEA
    positive regulation of SNARE complex assembly GO:0035543 ISO
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISO
Subcellular Localization
    brush border membrane GO:0031526 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 TAS
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 TAS
 Experiment description of studies that identified Tmem27 in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tmem27
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmem27 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here