Gene description for Cd86
Gene name CD86 molecule
Gene symbol Cd86
Other names/aliases B7-2
Species Rattus norvegicus
 Database cross references - Cd86
ExoCarta ExoCarta_56822
Entrez Gene 56822
 Cd86 identified in exosomes derived from the following tissue/cell type
Dendritic cells 19812188    
 Gene ontology annotations for Cd86
Molecular Function
    receptor binding GO:0005102 IPI
Biological Process
    response to yeast GO:0001878 IEP
    response to interferon-gamma GO:0034341 IEP
    positive regulation of T cell proliferation GO:0042102 ISO
    cellular response to metal ion GO:0071248 IEP
    negative regulation of T cell anergy GO:0002668 IMP
    B cell activation GO:0042113 ISO
    cellular response to cytokine stimulus GO:0071345 IEP
    myeloid dendritic cell differentiation GO:0043011 IEP
    response to lipopolysaccharide GO:0032496 IEP
    cellular response to lipopolysaccharide GO:0071222 ISO
    response to drug GO:0042493 IEP
    defense response to virus GO:0051607 ISO
    positive regulation of activated T cell proliferation GO:0042104 IDA
    toll-like receptor signaling pathway GO:0002224 ISO
    aging GO:0007568 IEP
    T cell proliferation involved in immune response GO:0002309 IEP
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    cell surface GO:0009986 ISO
    external side of plasma membrane GO:0009897 ISO
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cd86 in exosomes
1
Experiment ID 70
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19812188    
Organism Rattus norvegicus
Experiment description Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII.
Authors Miksa M, Wu R, Dong W, Komura H, Amin D, Ji Y, Wang Z, Wang H, Ravikumar TS, Tracey KJ, Wang P
Journal name JIMMU
Publication year 2009
Sample Dendritic cells
Sample name Bone marrow-derived mature dendritic cells
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Cd86
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd86 is involved
No pathways found





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