Gene description for SUCNR1
Gene name succinate receptor 1
Gene symbol SUCNR1
Other names/aliases GPR91
Species Homo sapiens
 Database cross references - SUCNR1
ExoCarta ExoCarta_56670
Vesiclepedia VP_56670
Entrez Gene 56670
HGNC 4542
MIM 606381
UniProt Q9BXA5  
 SUCNR1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SUCNR1
Molecular Function
    G protein-coupled receptor activity GO:0004930 IDA
    G protein-coupled receptor activity GO:0004930 ISS
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IBA
Biological Process
    renin secretion into blood stream GO:0002001 IEA
    macrophage activation involved in immune response GO:0002281 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    glucose homeostasis GO:0042593 IEA
    positive regulation of inflammatory response GO:0050729 IEA
    positive regulation of chemotaxis GO:0050921 IEA
    response to calcium ion GO:0051592 IEA
    regulation of angiotensin metabolic process GO:0060177 IEA
    energy homeostasis GO:0097009 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SUCNR1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SUCNR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRMT8  
Affinity Capture-MS Homo sapiens
2 MTCH2 23788
Affinity Capture-MS Homo sapiens
3 TMEM14B  
Two-hybrid Homo sapiens
View the network image/svg+xml



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