Gene description for Zbtb20
Gene name zinc finger and BTB domain containing 20
Gene symbol Zbtb20
Other names/aliases 1300017A20Rik
7330412A13Rik
A930017C21Rik
D16Wsu73e
DPZF
HOF
ODA-8S
Oda8
Zfp288
Species Mus musculus
 Database cross references - Zbtb20
ExoCarta ExoCarta_56490
Vesiclepedia VP_56490
Entrez Gene 56490
UniProt Q8K0L9  
 Zbtb20 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zbtb20
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA binding GO:0003677 IDA
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
    negative regulation of gene expression GO:0010629 IMP
    positive regulation of interferon-beta production GO:0032728 IDA
    positive regulation of interferon-beta production GO:0032728 IMP
    positive regulation of interleukin-6 production GO:0032755 IDA
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    positive regulation of glycolytic process GO:0045821 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of lipid biosynthetic process GO:0046889 IMP
    lipid homeostasis GO:0055088 IMP
    cellular response to glucose stimulus GO:0071333 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Zbtb20 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zbtb20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Prdm4  
Co-fractionation Mus musculus
2 Zfp652  
Co-fractionation Mus musculus
3 Zbtb17  
Co-fractionation Mus musculus
4 Zfp287  
Co-fractionation Mus musculus
5 Zfp667  
Co-fractionation Mus musculus
6 Zfp932  
Co-fractionation Mus musculus
7 Zbtb14  
Co-fractionation Mus musculus
8 Zfp697  
Co-fractionation Mus musculus
9 Zfp37  
Co-fractionation Mus musculus
10 Zfp746  
Co-fractionation Mus musculus
11 Zfp93  
Co-fractionation Mus musculus
12 Zfp423  
Co-fractionation Mus musculus
13 Zfp92  
Co-fractionation Mus musculus
14 Zfp27  
Co-fractionation Mus musculus
15 Zfp28  
Co-fractionation Mus musculus
16 Sall3  
Co-fractionation Mus musculus
17 Gzf1  
Co-fractionation Mus musculus
18 Zbtb48  
Co-fractionation Mus musculus
19 Zfp128  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zbtb20 is involved
No pathways found





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