Gene description for CCL28
Gene name chemokine (C-C motif) ligand 28
Gene symbol CCL28
Other names/aliases CCK1
MEC
SCYA28
Species Homo sapiens
 Database cross references - CCL28
ExoCarta ExoCarta_56477
Entrez Gene 56477
HGNC 17700
MIM 605240
UniProt Q9NRJ3  
 CCL28 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Saliva 19199708    
 Gene ontology annotations for CCL28
Molecular Function
    chemokine activity GO:0008009 TAS
    protein binding GO:0005515 IPI
Biological Process
    cell chemotaxis GO:0060326 IDA
    immune response GO:0006955 IEA
    chemotaxis GO:0006935 TAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    negative regulation of leukocyte tethering or rolling GO:1903237 IDA
    response to nutrient GO:0007584 IEA
    positive regulation of cell-matrix adhesion GO:0001954 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 IEA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CCL28 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CCL28
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CCL28 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome
G alpha (i) signalling events TAS Reactome





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