Gene description for Hsd17b12
Gene name hydroxysteroid (17-beta) dehydrogenase 12
Gene symbol Hsd17b12
Other names/aliases 2610510O05Rik
AI172963
KIK-I
Kik1
Species Mus musculus
 Database cross references - Hsd17b12
ExoCarta ExoCarta_56348
Vesiclepedia VP_56348
Entrez Gene 56348
UniProt O70503  
 Hsd17b12 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Hsd17b12
Molecular Function
    fibronectin binding GO:0001968 IDA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IEA
    collagen binding GO:0005518 IDA
    heparin binding GO:0008201 IDA
    oxidoreductase activity GO:0016491 IBA
    very-long-chain 3-oxoacyl-CoA reductase activity GO:0141040 IEA
    very-long-chain 3-oxoacyl-CoA reductase activity GO:0141040 ISO
Biological Process
    estrogen biosynthetic process GO:0006703 IEA
    positive regulation of cell-substrate adhesion GO:0010811 IDA
    fatty acid elongation, saturated fatty acid GO:0019367 IEA
    fatty acid elongation, saturated fatty acid GO:0019367 ISO
    extracellular matrix organization GO:0030198 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    fatty acid elongase complex GO:0009923 IEA
    fatty acid elongase complex GO:0009923 ISO
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified Hsd17b12 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hsd17b12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Atg16l1  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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