Gene description for Psmg1
Gene name proteasome (prosome, macropain) assembly chaperone 1
Gene symbol Psmg1
Other names/aliases AW552102
Dscr2
Species Mus musculus
 Database cross references - Psmg1
ExoCarta ExoCarta_56088
Vesiclepedia VP_56088
Entrez Gene 56088
UniProt Q9JK23  
 Psmg1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Psmg1
Molecular Function
    molecular adaptor activity GO:0060090 IEA
    molecular adaptor activity GO:0060090 ISO
    proteasome binding GO:0070628 IBA
    proteasome binding GO:0070628 IDA
Biological Process
    cerebellar granule cell precursor proliferation GO:0021930 IMP
    chaperone-mediated protein complex assembly GO:0051131 ISO
    chaperone-mediated protein complex assembly GO:0051131 ISS
    proteasome core complex assembly GO:0080129 IBA
    proteasome core complex assembly GO:0080129 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    protein folding chaperone complex GO:0101031 IEA
    protein folding chaperone complex GO:0101031 ISO
 Experiment description of studies that identified Psmg1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Psmg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Apex1  
Co-fractionation Mus musculus
2 Capza1 12340
Co-fractionation Mus musculus
3 Sec23a  
Co-fractionation Mus musculus
4 Nol3  
Co-fractionation Mus musculus
5 Aco1 11428
Co-fractionation Mus musculus
6 Psma2 19166
Co-fractionation Mus musculus
7 Capza2 12343
Co-fractionation Mus musculus
8 Lgals1 16852
Co-fractionation Mus musculus
9 Psmg2  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Psmg1 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
Proteasome assembly IEA Reactome





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