Gene description for Hgs
Gene name	hepatocyte growth factor-regulated tyrosine kinase substrate
Gene symbol	Hgs
Other names/aliases	Hrs
Species	Rattus norvegicus
Database cross references - Hgs
ExoCarta	ExoCarta_56084
Vesiclepedia	VP_56084
Entrez Gene	56084
UniProt	Q9JJ50
Hgs identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Hgs

Molecular Function     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IEA     protein domain specific binding GO:0019904 ISO     protein domain specific binding GO:0019904 NAS     phosphatidylinositol binding GO:0035091 IEA     identical protein binding GO:0042802 ISO     ubiquitin binding GO:0043130 IBA     ubiquitin binding GO:0043130 IEA     ubiquitin-like protein ligase binding GO:0044389 IEA     ubiquitin-like protein ligase binding GO:0044389 ISO     metal ion binding GO:0046872 IEA     ubiquitin-modified protein reader activity GO:0140036 ISO Biological Process     protein targeting to lysosome GO:0006622 IEA     protein targeting to lysosome GO:0006622 ISO     endosome to lysosome transport GO:0008333 IMP     membrane invagination GO:0010324 IEA     membrane invagination GO:0010324 ISO     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IEA     negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISO     protein transport GO:0015031 IEA     negative regulation of angiogenesis GO:0016525 IEA     negative regulation of angiogenesis GO:0016525 ISO     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IEA     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISO     receptor internalization GO:0031623 IBA     endocytic recycling GO:0032456 IBA     regulation of MAP kinase activity GO:0043405 ISO     negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA     negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISO     protein localization to membrane GO:0072657 IEA     protein localization to membrane GO:0072657 ISO     positive regulation of exosomal secretion GO:1903543 IEA     positive regulation of exosomal secretion GO:1903543 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     lysosome GO:0005764 IEA     lysosome GO:0005764 ISO     endosome GO:0005768 ISO     early endosome GO:0005769 IBA     early endosome GO:0005769 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     secretory granule GO:0030141 IDA     early endosome membrane GO:0031901 IEA     multivesicular body membrane GO:0032585 IEA     ESCRT-0 complex GO:0033565 IEA     ESCRT-0 complex GO:0033565 ISO