Gene description for PDGFC
Gene name platelet derived growth factor C
Gene symbol PDGFC
Other names/aliases FALLOTEIN
SCDGF
Species Homo sapiens
 Database cross references - PDGFC
ExoCarta ExoCarta_56034
Entrez Gene 56034
HGNC 8801
MIM 608452
UniProt Q9NRA1  
 PDGFC identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Saliva 19199708    
 Gene ontology annotations for PDGFC
Molecular Function
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
    platelet-derived growth factor receptor binding GO:0005161 IPI
Biological Process
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IEA
    positive regulation of cell division GO:0051781 IEA
    embryo development GO:0009790 IEA
    activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IDA
    central nervous system development GO:0007417 TAS
    organ morphogenesis GO:0009887 IEA
    positive regulation of DNA replication GO:0045740 IDA
    cellular response to amino acid stimulus GO:0071230 IEA
    positive regulation of fibroblast proliferation GO:0048146 IDA
Subcellular Localization
    cell surface GO:0009986 IDA
    extracellular region GO:0005576 TAS
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    Golgi membrane GO:0000139 TAS
    nucleus GO:0005634 IEA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified PDGFC in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for PDGFC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDGFRA  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PDGFC is involved
No pathways found





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