Gene description for SYTL2
Gene name synaptotagmin-like 2
Gene symbol SYTL2
Other names/aliases CHR11SYT
EXO4
PPP1R151
SGA72M
SLP2
SLP2A
Species Homo sapiens
 Database cross references - SYTL2
ExoCarta ExoCarta_54843
Entrez Gene 54843
HGNC 15585
MIM 612880
UniProt Q9HCH5  
 SYTL2 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SYTL2
Molecular Function
    calcium-dependent phospholipid binding GO:0005544 IBA
    syntaxin binding GO:0019905 IBA
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IMP
    phosphatidylserine binding GO:0001786 IMP
    neurexin family protein binding GO:0042043 ISS
    clathrin binding GO:0030276 IBA
    phosphatase binding GO:0019902 IDA
    Rab GTPase binding GO:0017137 IEA
Biological Process
    negative regulation of phosphatase activity GO:0010923 IDA
    exocytosis GO:0006887 IDA
    intracellular protein transport GO:0006886 IEA
    vesicle docking involved in exocytosis GO:0006904 IDA
    synaptic vesicle exocytosis GO:0016079 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
    vesicle-mediated transport GO:0016192 ISS
    positive regulation of mucus secretion GO:0070257 IEA
Subcellular Localization
    extrinsic component of plasma membrane GO:0019897 ISS
    nucleus GO:0005634 IDA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 ISS
    nucleoplasm GO:0005654 IDA
    melanosome GO:0042470 ISS
    plasma membrane GO:0005886 IDA
    exocytic vesicle GO:0070382 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SYTL2 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SYTL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB27A 5873
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
2 PPP1CA 5499
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYTL2 is involved
No pathways found





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