Gene description for Cadm1
Gene name cell adhesion molecule 1
Gene symbol Cadm1
Other names/aliases 2900073G06Rik
3100001I08Rik
AI987920
Bl2
Igsf4
Igsf4a
Necl2
RA175
RA175A
RA175B
RA175C
RA175N
ST17
SgIGSF
SynCam
Tslc1
Species Mus musculus
 Database cross references - Cadm1
ExoCarta ExoCarta_54725
Vesiclepedia VP_54725
Entrez Gene 54725
UniProt Q8R5M8  
 Cadm1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cadm1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IPI
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 IPI
    protein homodimerization activity GO:0042803 IDA
    cell adhesion molecule binding GO:0050839 ISO
Biological Process
    positive regulation of cytokine production GO:0001819 ISO
    liver development GO:0001889 ISO
    negative regulation of protein phosphorylation GO:0001933 ISO
    apoptotic process GO:0006915 IEA
    cell adhesion GO:0007155 IDA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP
    spermatogenesis GO:0007283 IEA
    synapse assembly GO:0007416 IDA
    synapse assembly GO:0007416 IDA
    synapse assembly GO:0007416 IMP
    cell recognition GO:0008037 IBA
    cell recognition GO:0008037 IDA
    cell recognition GO:0008037 ISO
    unidimensional cell growth GO:0009826 IMP
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 IDA
    cell differentiation GO:0030154 IEA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 IBA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 IDA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IDA
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
    detection of stimulus GO:0051606 IBA
    detection of stimulus GO:0051606 IDA
    detection of stimulus GO:0051606 ISO
    bone development GO:0060348 IMP
    lymphocyte migration into lymphoid organs GO:0097021 IMP
    maintenance of postsynaptic specialization structure GO:0098880 IDA
    maintenance of postsynaptic specialization structure GO:0098880 IMP
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 IDA
    retrograde trans-synaptic signaling by trans-synaptic protein complex GO:0098942 IMP
    presynapse assembly GO:0099054 IDA
    presynapse assembly GO:0099054 IMP
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IEP
    negative regulation of ERBB4 signaling pathway GO:0120154 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IDA
    synaptic vesicle GO:0008021 IDA
    postsynaptic density GO:0014069 ISO
    basolateral plasma membrane GO:0016323 IDA
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISO
    presynaptic membrane GO:0042734 IDA
    neuron projection GO:0043005 IBA
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Cadm1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cadm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pip4k2c  
Co-fractionation Mus musculus
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