Gene description for Iqgap2
Gene name IQ motif containing GTPase activating protein 2
Gene symbol Iqgap2
Other names/aliases 4933417J23Rik
A630053O10
AI788777
Species Mus musculus
 Database cross references - Iqgap2
ExoCarta ExoCarta_544963
Vesiclepedia VP_544963
Entrez Gene 544963
UniProt Q3UQ44  
 Iqgap2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Iqgap2
Molecular Function
    GTPase activator activity GO:0005096 IBA
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 IEA
    calmodulin binding GO:0005516 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISS
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IEA
    actin filament binding GO:0051015 ISO
    Arp2/3 complex binding GO:0071933 IEA
    Arp2/3 complex binding GO:0071933 ISO
Biological Process
    regulation of actin cytoskeleton organization GO:0032956 IEA
    regulation of actin cytoskeleton organization GO:0032956 ISO
    Arp2/3 complex-mediated actin nucleation GO:0034314 IEA
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
    thrombin-activated receptor signaling pathway GO:0070493 IEA
    thrombin-activated receptor signaling pathway GO:0070493 ISO
    mitotic actomyosin contractile ring assembly actin filament organization GO:1903479 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    microtubule GO:0005874 ISO
    microvillus GO:0005902 IDA
    cell cortex GO:0005938 IBA
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    filopodium GO:0030175 IEA
    filopodium GO:0030175 ISO
 Experiment description of studies that identified Iqgap2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Iqgap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Syngap1  
Affinity Capture-MS Mus musculus
2 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Dlg4  
Affinity Capture-MS Mus musculus
5 Chuk  
Co-fractionation Mus musculus
6 Agap2  
Affinity Capture-MS Mus musculus
7 Tnip2  
Co-fractionation Mus musculus
8 Akap8l  
Co-fractionation Mus musculus
9 Fancd2  
Affinity Capture-MS Mus musculus
10 Lrpprc  
Co-fractionation Mus musculus
11 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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