Gene description for Ezr
Gene name	ezrin
Gene symbol	Ezr
Other names/aliases	Vil2
Species	Rattus norvegicus
Database cross references - Ezr
ExoCarta	ExoCarta_54319
Vesiclepedia	VP_54319
Entrez Gene	54319
UniProt	P31977
Ezr identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Ezr

Molecular Function     actin binding GO:0003779 IBA     actin binding GO:0003779 IEA     actin binding GO:0003779 ISO     structural molecule activity GO:0005198 TAS     protein binding GO:0005515 IPI     microtubule binding GO:0008017 IEA     microtubule binding GO:0008017 ISO     protein domain specific binding GO:0019904 IPI     protein domain specific binding GO:0019904 ISO     protein kinase A catalytic subunit binding GO:0034236 IEA     protein kinase A catalytic subunit binding GO:0034236 ISO     protein kinase A regulatory subunit binding GO:0034237 IEA     protein kinase A regulatory subunit binding GO:0034237 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     S100 protein binding GO:0044548 IEA     S100 protein binding GO:0044548 ISO     protein-containing complex binding GO:0044877 IPI     cell adhesion molecule binding GO:0050839 IBA     cell adhesion molecule binding GO:0050839 IEA     cell adhesion molecule binding GO:0050839 ISO     cell adhesion molecule binding GO:0050839 ISS     actin filament binding GO:0051015 IEA     actin filament binding GO:0051015 ISO     actin filament binding GO:0051015 ISS     protein kinase A binding GO:0051018 ISO     ATPase binding GO:0051117 IEA     ATPase binding GO:0051117 ISO     disordered domain specific binding GO:0097718 IEA     disordered domain specific binding GO:0097718 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     intestinal D-glucose absorption GO:0001951 IEA     intestinal D-glucose absorption GO:0001951 ISO     sphingosine-1-phosphate receptor signaling pathway GO:0003376 IEA     sphingosine-1-phosphate receptor signaling pathway GO:0003376 ISO     leukocyte cell-cell adhesion GO:0007159 IEA     leukocyte cell-cell adhesion GO:0007159 ISO     regulation of cell shape GO:0008360 IBA     regulation of cell shape GO:0008360 IEA     regulation of cell shape GO:0008360 ISO     regulation of cell size GO:0008361 ISO     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     protein kinase A signaling GO:0010737 IEA     protein kinase A signaling GO:0010737 ISO     gland morphogenesis GO:0022612 ISO     membrane to membrane docking GO:0022614 IEA     membrane to membrane docking GO:0022614 ISO     microvillus assembly GO:0030033 IEA     microvillus assembly GO:0030033 ISO     microvillus assembly GO:0030033 ISO     actin cytoskeleton organization GO:0030036 ISO     epithelial cell differentiation GO:0030855 IEP     astral microtubule organization GO:0030953 IEA     astral microtubule organization GO:0030953 ISO     protein-containing complex localization GO:0031503 IEA     protein-containing complex localization GO:0031503 ISO     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     regulation of microvillus length GO:0032532 IEA     regulation of microvillus length GO:0032532 ISO     negative regulation of interleukin-2 production GO:0032703 IEA     negative regulation of interleukin-2 production GO:0032703 ISO     regulation of actin cytoskeleton organization GO:0032956 ISO     establishment or maintenance of apical/basal cell polarity GO:0035088 IEA     establishment or maintenance of apical/basal cell polarity GO:0035088 ISO     positive regulation of multicellular organism growth GO:0040018 IEA     positive regulation of multicellular organism growth GO:0040018 ISO     cortical microtubule organization GO:0043622 IEA     cortical microtubule organization GO:0043622 ISO     establishment of epithelial cell apical/basal polarity GO:0045198 ISO     positive regulation of protein catabolic process GO:0045732 IEA     positive regulation of protein catabolic process GO:0045732 ISO     filopodium assembly GO:0046847 IEA     filopodium assembly GO:0046847 IMP     filopodium assembly GO:0046847 ISO     negative regulation of T cell receptor signaling pathway GO:0050860 IEA     negative regulation of T cell receptor signaling pathway GO:0050860 ISO     actin filament bundle assembly GO:0051017 IEA     actin filament bundle assembly GO:0051017 ISO     actin filament bundle assembly GO:0051017 ISS     establishment of centrosome localization GO:0051660 IEA     establishment of centrosome localization GO:0051660 ISO     establishment of endothelial barrier GO:0061028 IEA     establishment of endothelial barrier GO:0061028 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     cellular response to cAMP GO:0071320 IEA     cellular response to cAMP GO:0071320 ISO     protein localization to plasma membrane GO:0072659 IEA     protein localization to plasma membrane GO:0072659 ISO     protein localization to cell cortex GO:0072697 IEA     protein localization to cell cortex GO:0072697 ISO     postsynaptic actin cytoskeleton organization GO:0098974 IEA     postsynaptic actin cytoskeleton organization GO:0098974 ISO     regulation of non-canonical NF-kappaB signal transduction GO:1901222 ISO     regulation of organelle assembly GO:1902115 IBA     regulation of organelle assembly GO:1902115 IEA     regulation of organelle assembly GO:1902115 ISO     terminal web assembly GO:1902896 IEA     terminal web assembly GO:1902896 ISO     positive regulation of protein localization to early endosome GO:1902966 IBA     positive regulation of protein localization to early endosome GO:1902966 IEA     positive regulation of protein localization to early endosome GO:1902966 ISO     positive regulation of protein localization to plasma membrane GO:1903078 IEA     positive regulation of protein localization to plasma membrane GO:1903078 ISO     negative regulation of p38MAPK cascade GO:1903753 IEA     negative regulation of p38MAPK cascade GO:1903753 ISO     positive regulation of early endosome to late endosome transport GO:2000643 IBA     positive regulation of early endosome to late endosome transport GO:2000643 IEA     positive regulation of early endosome to late endosome transport GO:2000643 ISO Subcellular Localization     fibrillar center GO:0001650 IEA     fibrillar center GO:0001650 ISO     ruffle GO:0001726 ISO     immunological synapse GO:0001772 IEA     immunological synapse GO:0001772 ISO     uropod GO:0001931 IEA     uropod GO:0001931 ISO     cytoplasm GO:0005737 ISO     endosome GO:0005768 IEA     endosome GO:0005768 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     actin filament GO:0005884 IEA     actin filament GO:0005884 ISO     actin filament GO:0005884 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     microvillus GO:0005902 IBA     microvillus GO:0005902 ISO     brush border GO:0005903 IEA     brush border GO:0005903 ISO     adherens junction GO:0005912 IBA     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     cell cortex GO:0005938 IEA     actin cytoskeleton GO:0015629 ISO     actin cytoskeleton GO:0015629 ISS     basolateral plasma membrane GO:0016323 IDA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     filopodium GO:0030175 IBA     filopodium GO:0030175 IDA     filopodium GO:0030175 IEA     filopodium GO:0030175 ISO     T-tubule GO:0030315 IDA     microvillus membrane GO:0031528 IDA     microvillus membrane GO:0031528 IEA     ruffle membrane GO:0032587 IEA     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO     ciliary basal body GO:0036064 IEA     ciliary basal body GO:0036064 ISO     cell projection GO:0042995 ISO     cell body GO:0044297 IDA     microspike GO:0044393 IDA     plasma membrane raft GO:0044853 IEA     plasma membrane raft GO:0044853 ISO     apical part of cell GO:0045177 IBA     apical part of cell GO:0045177 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     cell tip GO:0051286 IDA     cell periphery GO:0071944 ISO     astrocyte projection GO:0097449 IDA     Schwann cell microvillus GO:0097454 IDA