Gene description for CLIC6
Gene name chloride intracellular channel 6
Gene symbol CLIC6
Other names/aliases CLIC1L
Species Homo sapiens
 Database cross references - CLIC6
ExoCarta ExoCarta_54102
Entrez Gene 54102
HGNC 2065
MIM 615321
UniProt Q96NY7  
 CLIC6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for CLIC6
Molecular Function
    D4 dopamine receptor binding GO:0031751 IEA
    chloride channel activity GO:0005254 IEA
    protein homodimerization activity GO:0042803 IEA
    D2 dopamine receptor binding GO:0031749 IEA
    protein C-terminus binding GO:0008022 IEA
    voltage-gated ion channel activity GO:0005244 IEA
    D3 dopamine receptor binding GO:0031750 IEA
Biological Process
    regulation of ion transmembrane transport GO:0034765 IEA
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    chloride channel complex GO:0034707 IEA
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified CLIC6 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CLIC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DRD4  
Two-hybrid Homo sapiens
2 DRD2  
Two-hybrid Homo sapiens
3 DRD3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CLIC6 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here