Gene description for Nudt5
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 5
Gene symbol Nudt5
Other names/aliases -
Species Mus musculus
 Database cross references - Nudt5
ExoCarta ExoCarta_53893
Vesiclepedia VP_53893
Entrez Gene 53893
UniProt Q9JKX6  
 Nudt5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Nudt5
Molecular Function
    magnesium ion binding GO:0000287 ISO
    magnesium ion binding GO:0000287 ISS
    nucleotidyltransferase activity GO:0016779 ISO
    nucleotidyltransferase activity GO:0016779 ISS
    nucleoside diphosphate phosphatase activity GO:0017110 IDA
    ADP-sugar diphosphatase activity GO:0019144 ISO
    ADP-sugar diphosphatase activity GO:0019144 ISS
    snoRNA binding GO:0030515 IDA
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    8-oxo-dGDP phosphatase activity GO:0044715 ISO
    8-oxo-dGDP phosphatase activity GO:0044715 ISS
    8-oxo-GDP phosphatase activity GO:0044716 IEA
    ADP-ribose diphosphatase activity GO:0047631 IBA
    ADP-ribose diphosphatase activity GO:0047631 ISO
    ADP-ribose diphosphatase activity GO:0047631 ISS
    5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity GO:0140933 IDA
Biological Process
    nucleobase-containing compound metabolic process GO:0006139 IDA
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 ISS
    nucleoside phosphate metabolic process GO:0006753 IBA
    ribonucleoside diphosphate catabolic process GO:0009191 ISO
    ribonucleoside diphosphate catabolic process GO:0009191 ISS
    D-ribose catabolic process GO:0019303 ISO
    D-ribose catabolic process GO:0019303 ISS
    ribose phosphate metabolic process GO:0019693 IBA
    ATP generation from poly-ADP-D-ribose GO:1990966 IEA
    ATP generation from poly-ADP-D-ribose GO:1990966 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
 Experiment description of studies that identified Nudt5 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nudt5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
2 Foxp3  
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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