Gene description for Slc5a3
Gene name solute carrier family 5 (inositol transporters), member 3
Gene symbol Slc5a3
Other names/aliases AA623876
BF642829
Smit1
Species Mus musculus
 Database cross references - Slc5a3
ExoCarta ExoCarta_53881
Vesiclepedia VP_53881
Entrez Gene 53881
UniProt Q9JKZ2  
 Slc5a3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc5a3
Molecular Function
    myo-inositol:sodium symporter activity GO:0005367 ISO
    D-glucose:sodium symporter activity GO:0005412 IBA
    D-glucose:sodium symporter activity GO:0005412 IEA
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 ISO
    transmembrane transporter binding GO:0044325 ISO
Biological Process
    inositol metabolic process GO:0006020 IBA
    inositol metabolic process GO:0006020 IMP
    peripheral nervous system development GO:0007422 IMP
    hexose transmembrane transport GO:0008645 IEA
    myo-inositol transport GO:0015798 IBA
    myo-inositol transport GO:0015798 IMP
    regulation of transporter activity GO:0032409 IDA
    sodium ion transmembrane transport GO:0035725 IEA
    positive regulation of catalytic activity GO:0043085 IMP
    regulation of respiratory gaseous exchange GO:0043576 IMP
    positive regulation of reactive oxygen species biosynthetic process GO:1903428 IMP
    positive regulation of protein localization to membrane GO:1905477 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    voltage-gated potassium channel complex GO:0008076 IDA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Slc5a3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc5a3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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