Gene description for Vti1b
Gene name vesicle transport through interaction with t-SNAREs 1B
Gene symbol Vti1b
Other names/aliases AU015348
GES30
MVti1b
SNARE
Vti1-rp1
Species Mus musculus
 Database cross references - Vti1b
ExoCarta ExoCarta_53612
Vesiclepedia VP_53612
Entrez Gene 53612
 Vti1b identified in sEVs derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Vti1b
Molecular Function
    SNARE binding GO:0000149 IBA
    SNARE binding GO:0000149 ISO
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    chloride channel inhibitor activity GO:0019869 ISO
Biological Process
    intracellular protein transport GO:0006886 IEA
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    Golgi to vacuole transport GO:0006896 IBA
    vesicle-mediated transport GO:0016192 IEA
    macroautophagy GO:0016236 IBA
    retrograde transport, endosome to Golgi GO:0042147 IBA
    vesicle fusion with Golgi apparatus GO:0048280 IBA
    regulation of protein localization to plasma membrane GO:1903076 IBA
    regulation of protein localization to plasma membrane GO:1903076 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    endoplasmic reticulum membrane GO:0005789 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    synaptic vesicle GO:0008021 ISO
    ER to Golgi transport vesicle membrane GO:0012507 IBA
    membrane GO:0016020 IDA
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 ISO
    early endosome membrane GO:0031901 IEA
    early endosome membrane GO:0031901 ISO
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 ISO
    late endosome membrane GO:0031902 ISS
    vesicle GO:0031982 ISO
    neuronal cell body GO:0043025 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome GO:0055037 ISO
    recycling endosome membrane GO:0055038 IEA
    recycling endosome membrane GO:0055038 ISO
 Experiment description of studies that identified Vti1b in sEVs
1
Experiment ID 14
MISEV standards
EM
Biophysical techniques
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
DNM
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Vti1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stx6  
Affinity Capture-Western Mus musculus
2 Stx7  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Vti1b is involved
No pathways found





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