Gene description for Pla2g6
Gene name	phospholipase A2, group VI
Gene symbol	Pla2g6
Other names/aliases	BB112799 PNPLA9 iPLA(2)beta iPLA2 iPLA2beta
Species	Mus musculus
Database cross references - Pla2g6
ExoCarta	ExoCarta_53357
Vesiclepedia	VP_53357
Entrez Gene	53357
UniProt	P97819
Pla2g6 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Pla2g6

Molecular Function     1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 ISS     lysophospholipase activity GO:0004622 ISO     lysophospholipase activity GO:0004622 ISS     calmodulin binding GO:0005516 IEA     serine hydrolase activity GO:0017171 IDA     protein kinase binding GO:0019901 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     ATP-dependent protein binding GO:0043008 ISO     calcium-dependent phospholipase A2 activity GO:0047498 IEA     calcium-independent phospholipase A2 activity GO:0047499 IBA     calcium-independent phospholipase A2 activity GO:0047499 IMP     calcium-independent phospholipase A2 activity GO:0047499 ISO     calcium-independent phospholipase A2 activity GO:0047499 ISS     long-chain fatty acyl-CoA hydrolase activity GO:0052816 IBA     long-chain fatty acyl-CoA hydrolase activity GO:0052816 IMP     long-chain fatty acyl-CoA hydrolase activity GO:0052816 ISO     long-chain fatty acyl-CoA hydrolase activity GO:0052816 ISS Biological Process     positive regulation of protein phosphorylation GO:0001934 ISO     chemotaxis GO:0006935 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 ISO     memory GO:0007613 ISO     urinary bladder smooth muscle contraction GO:0014832 ISO     antibacterial humoral response GO:0019731 IEA     antibacterial humoral response GO:0019731 ISO     cardiolipin biosynthetic process GO:0032049 IEA     cardiolipin biosynthetic process GO:0032049 ISO     phosphatidylcholine catabolic process GO:0034638 ISO     phosphatidylcholine catabolic process GO:0034638 ISS     response to endoplasmic reticulum stress GO:0034976 ISO     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISO     cardiolipin acyl-chain remodeling GO:0035965 IBA     cardiolipin acyl-chain remodeling GO:0035965 ISO     cardiolipin acyl-chain remodeling GO:0035965 ISS     vasodilation GO:0042311 ISO     positive regulation of exocytosis GO:0045921 ISO     phosphatidylethanolamine catabolic process GO:0046338 ISS     platelet activating factor metabolic process GO:0046469 ISS     phosphatidic acid metabolic process GO:0046473 ISS     negative regulation of synaptic transmission, glutamatergic GO:0051967 ISO     positive regulation of protein kinase C signaling GO:0090037 ISO     positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO     positive regulation of arachidonate secretion GO:0090238 ISO     positive regulation of ceramide biosynthetic process GO:2000304 IBA     positive regulation of ceramide biosynthetic process GO:2000304 ISO Subcellular Localization     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IEA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     microtubule cytoskeleton GO:0015630 IEA     microtubule cytoskeleton GO:0015630 ISO     nuclear speck GO:0016607 IEA     nuclear speck GO:0016607 ISO     pseudopodium GO:0031143 IEA