Gene description for CDC42
Gene name cell division cycle 42
Gene symbol CDC42
Other names/aliases -
Species Bos taurus
 Database cross references - CDC42
ExoCarta ExoCarta_532712
Vesiclepedia VP_532712
Entrez Gene 532712
UniProt Q2KJ93  
 CDC42 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CDC42
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IEA
    modification of synaptic structure GO:0099563 IEA
Subcellular Localization
    dendritic spine GO:0043197 IEA
 Experiment description of studies that identified CDC42 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDC42
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CDC42 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Axon guidance IEA Reactome
CD28 co-stimulation IEA Reactome
CD28 dependent Vav1 pathway IEA Reactome
CDC42 GTPase cycle IEA Reactome
Costimulation by the CD28 family IEA Reactome
DCC mediated attractive signaling IEA Reactome
Developmental Biology IEA Reactome
EGFR downregulation IEA Reactome
EPH-Ephrin signaling IEA Reactome
EPHB-mediated forward signaling IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
G beta:gamma signalling through CDC42 IEA Reactome
G-protein beta:gamma signalling IEA Reactome
GPCR downstream signalling IEA Reactome
GPVI-mediated activation cascade IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK6/MAPK4 signaling IEA Reactome
Myogenesis IEA Reactome
Nervous system development IEA Reactome
Netrin-1 signaling IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
RAC1 GTPase cycle IEA Reactome
RAC2 GTPase cycle IEA Reactome
RAC3 GTPase cycle IEA Reactome
Regulation of actin dynamics for phagocytic cup formation IEA Reactome
RHO GTPase cycle IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
RHO GTPases activate IQGAPs IEA Reactome
RHO GTPases activate KTN1 IEA Reactome
RHO GTPases activate PAKs IEA Reactome
RHO GTPases Activate WASPs and WAVEs IEA Reactome
RHOG GTPase cycle IEA Reactome
RHOQ GTPase cycle IEA Reactome
RHOU GTPase cycle IEA Reactome
RHOV GTPase cycle IEA Reactome
Signal Transduction IEA Reactome
Signaling by EGFR IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by VEGF IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome





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