Gene description for Rab10
Gene name RAB10, member RAS oncogene family
Gene symbol Rab10
Other names/aliases Ac1075
Species Rattus norvegicus
 Database cross references - Rab10
ExoCarta ExoCarta_50993
Entrez Gene 50993
 Rab10 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Rab10
Molecular Function
    GDP binding GO:0019003 ISS
    GTPase activity GO:0003924 ISO
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
    GTP binding GO:0005525 ISS
    myosin V binding GO:0031489 ISO
Biological Process
    antigen processing and presentation GO:0019882 ISO
    metabolic process GO:0008152 ISO
    endoplasmic reticulum tubular network organization GO:0071786 ISS
    Golgi to plasma membrane transport GO:0006893 IMP
    protein localization to plasma membrane GO:0072659 ISS
    cellular response to insulin stimulus GO:0032869 ISS
    establishment of protein localization to endoplasmic reticulum membrane GO:0097051 ISS
    polarized epithelial cell differentiation GO:0030859 ISS
    regulation of exocytosis GO:0017157 IBA
    Rab protein signal transduction GO:0032482 IBA
    intracellular protein transport GO:0006886 IBA
    vesicle-mediated transport GO:0016192 ISS
    axonogenesis GO:0007409 IMP
    Golgi to plasma membrane protein transport GO:0043001 ISS
    basolateral protein localization GO:0061467 ISS
    vesicle docking involved in exocytosis GO:0006904 IBA
    establishment of neuroblast polarity GO:0045200 IMP
    cellular response to antibiotic GO:0071236 IEP
    protein secretion GO:0009306 IBA
    establishment of protein localization to membrane GO:0090150 ISO
    endosomal transport GO:0016197 ISS
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 ISS
    recycling endosome GO:0055037 ISS
    endosome GO:0005768 ISS
    insulin-responsive compartment GO:0032593 ISS
    membrane GO:0016020 IDA
    primary cilium GO:0072372 ISO
    Golgi apparatus GO:0005794 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    endoplasmic reticulum tubular network GO:0071782 ISS
    phagocytic vesicle membrane GO:0030670 IEA
    endoplasmic reticulum membrane GO:0005789 ISS
    exocyst GO:0000145 ISS
    endosome membrane GO:0010008 IBA
    recycling endosome membrane GO:0055038 IEA
 Experiment description of studies that identified Rab10 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rab10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab10 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here