Gene description for Xdh
Gene name	xanthine dehydrogenase
Gene symbol	Xdh
Other names/aliases	XOR
Species	Rattus norvegicus
Database cross references - Xdh
ExoCarta	ExoCarta_497811
Vesiclepedia	VP_497811
Entrez Gene	497811
UniProt	P22985
Xdh identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041

Gene ontology annotations for Xdh

Molecular Function     xanthine dehydrogenase activity GO:0004854 IBA     xanthine dehydrogenase activity GO:0004854 IDA     xanthine dehydrogenase activity GO:0004854 IEA     xanthine dehydrogenase activity GO:0004854 ISO     xanthine oxidase activity GO:0004855 IDA     xanthine oxidase activity GO:0004855 IEA     xanthine oxidase activity GO:0004855 ISO     xanthine oxidase activity GO:0004855 ISS     iron ion binding GO:0005506 IEA     oxidoreductase activity GO:0016491 IEA     oxidoreductase activity GO:0016491 ISO     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     molybdopterin cofactor binding GO:0043546 IDA     molybdopterin cofactor binding GO:0043546 IEA     molybdopterin cofactor binding GO:0043546 ISO     molybdopterin cofactor binding GO:0043546 ISS     nitrite reductase (NO-forming) activity GO:0050421 IDA     flavin adenine dinucleotide binding GO:0050660 IDA     flavin adenine dinucleotide binding GO:0050660 ISO     flavin adenine dinucleotide binding GO:0050660 ISS     2 iron, 2 sulfur cluster binding GO:0051537 IDA     2 iron, 2 sulfur cluster binding GO:0051537 IEA     2 iron, 2 sulfur cluster binding GO:0051537 ISO     2 iron, 2 sulfur cluster binding GO:0051537 ISS     hypoxanthine dehydrogenase activity GO:0070674 IEA     hypoxanthine dehydrogenase activity GO:0070674 ISO     hypoxanthine oxidase activity GO:0070675 IEA     hypoxanthine oxidase activity GO:0070675 ISO     FAD binding GO:0071949 IEA Biological Process     allantoin metabolic process GO:0000255 IDA     allantoin metabolic process GO:0000255 IEA     allantoin metabolic process GO:0000255 ISO     negative regulation of protein phosphorylation GO:0001933 ISO     negative regulation of endothelial cell proliferation GO:0001937 IEA     negative regulation of endothelial cell proliferation GO:0001937 ISO     guanine catabolic process GO:0006147 IDA     guanine catabolic process GO:0006147 IEA     guanine catabolic process GO:0006147 ISO     inosine catabolic process GO:0006148 IDA     inosine catabolic process GO:0006148 IEA     inosine catabolic process GO:0006148 ISO     deoxyinosine catabolic process GO:0006149 IEA     deoxyinosine catabolic process GO:0006149 ISO     adenosine catabolic process GO:0006154 IDA     adenosine catabolic process GO:0006154 IEA     adenosine catabolic process GO:0006154 ISO     deoxyadenosine catabolic process GO:0006157 IEA     deoxyadenosine catabolic process GO:0006157 ISO     deoxyguanosine catabolic process GO:0006161 IEA     deoxyguanosine catabolic process GO:0006161 ISO     AMP catabolic process GO:0006196 IEA     AMP catabolic process GO:0006196 ISO     IMP catabolic process GO:0006204 IEA     IMP catabolic process GO:0006204 ISO     lactation GO:0007595 IEA     lactation GO:0007595 ISO     hypoxanthine catabolic process GO:0009114 IDA     hypoxanthine catabolic process GO:0009114 IEA     hypoxanthine catabolic process GO:0009114 ISO     xanthine catabolic process GO:0009115 IBA     xanthine catabolic process GO:0009115 IDA     xanthine catabolic process GO:0009115 IEA     xanthine catabolic process GO:0009115 ISO     xanthine catabolic process GO:0009115 ISS     response to aluminum ion GO:0010044 IDA     negative regulation of gene expression GO:0010629 IEA     negative regulation of gene expression GO:0010629 ISO     iron-sulfur cluster assembly GO:0016226 IEA     iron-sulfur cluster assembly GO:0016226 ISO     regulation of epithelial cell differentiation GO:0030856 ISO     response to lipopolysaccharide GO:0032496 IEP     response to carbon monoxide GO:0034465 IEP     response to hydrogen peroxide GO:0042542 IEP     amide catabolic process GO:0043605 IEA     amide catabolic process GO:0043605 ISO     negative regulation of endothelial cell differentiation GO:0045602 IEA     negative regulation of endothelial cell differentiation GO:0045602 ISO     GMP catabolic process GO:0046038 IEA     GMP catabolic process GO:0046038 ISO     dGMP catabolic process GO:0046055 IEA     dGMP catabolic process GO:0046055 ISO     dAMP catabolic process GO:0046059 IEA     dAMP catabolic process GO:0046059 ISO     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IEA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO     cellular response to interleukin-1 GO:0071347 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     response to azide GO:0097184 IEP     positive regulation of p38MAPK cascade GO:1900745 IEA     positive regulation of p38MAPK cascade GO:1900745 ISO     negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IEA     negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 ISO     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 ISO     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO     negative regulation of vasculogenesis GO:2001213 IEA     negative regulation of vasculogenesis GO:2001213 ISO Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     peroxisome GO:0005777 IDA     peroxisome GO:0005777 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     sarcoplasmic reticulum GO:0016529 IEA     sarcoplasmic reticulum GO:0016529 ISO