Gene description for UNC13C
Gene name unc-13 homolog C (C. elegans)
Gene symbol UNC13C
Other names/aliases -
Species Homo sapiens
 Database cross references - UNC13C
ExoCarta ExoCarta_440279
Vesiclepedia VP_440279
Entrez Gene 440279
HGNC 23149
MIM 614568
UniProt Q8NB66  
 UNC13C identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for UNC13C
Molecular Function
    calcium ion binding GO:0005509 IEA
    calmodulin binding GO:0005516 IBA
    phospholipid binding GO:0005543 IEA
    syntaxin-1 binding GO:0017075 IBA
    diacylglycerol binding GO:0019992 IEA
Biological Process
    chemical synaptic transmission GO:0007268 ISS
    synaptic vesicle docking GO:0016081 IBA
    synaptic vesicle priming GO:0016082 IBA
    negative regulation of synaptic plasticity GO:0031914 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    dense core granule priming GO:0061789 IBA
    presynaptic dense core vesicle exocytosis GO:0099525 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    synaptic vesicle membrane GO:0030672 IBA
    neuromuscular junction GO:0031594 IBA
    presynaptic membrane GO:0042734 IBA
    terminal bouton GO:0043195 IBA
    calyx of Held GO:0044305 IEA
    presynaptic active zone GO:0048786 TAS
    parallel fiber to Purkinje cell synapse GO:0098688 IEA
    presynaptic active zone cytoplasmic component GO:0098831 IBA
 Experiment description of studies that identified UNC13C in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UNC13C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PGAM1 5223
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST3H2A 92815
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which UNC13C is involved
No pathways found





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