Gene description for ASMT
Gene name acetylserotonin O-methyltransferase
Gene symbol ASMT
Other names/aliases ASMTY
HIOMT
HIOMTY
Species Homo sapiens
 Database cross references - ASMT
ExoCarta ExoCarta_438
Vesiclepedia VP_438
Entrez Gene 438
HGNC 750
MIM 300015
UniProt P46597  
 ASMT identified in sEVs derived from the following tissue/cell type
Cholangiocarcinoma cells 31054213    
Cholangiocarcinoma cells 31054213    
 Gene ontology annotations for ASMT
Molecular Function
    O-methyltransferase activity GO:0008171 TAS
    S-methyltransferase activity GO:0008172 TAS
    acetylserotonin O-methyltransferase activity GO:0017096 IBA
    acetylserotonin O-methyltransferase activity GO:0017096 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    translation GO:0006412 TAS
    lipid metabolic process GO:0006629 IEA
    melatonin biosynthetic process GO:0030187 IBA
    melatonin biosynthetic process GO:0030187 IDA
    melatonin biosynthetic process GO:0030187 IEA
    methylation GO:0032259 IBA
    indolalkylamine biosynthetic process GO:0046219 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ASMT in sEVs
1
Experiment ID 1223
MISEV standards
✔
EM
Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors "Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C."
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213 - in-gel digestion
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 1224
MISEV standards
✔
EM
Biophysical techniques
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors "Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C."
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213D5 - in-gel digestion
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ASMT
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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